In This Issue:
- Information Day on Progress in Alternative Methods in Toxicology and Biomedicine
- CAAT Academy Returns After the Summer with Two Sessions
- CAAT's Mini-Brain Research Featured in Hopkins Bloomberg Public Health Magazine
- Thomas Hartung Quoted in Article About TSCA
- ALTEX Impact Factor Rises to 5.824
- Video: Thomas Hartung on Promoting Dialogue Between In Vivo, In Vitro, and In Silica at the IRCS Institute for Pharmacological Research in Milan
- NICEATM Requests Data and Information on Developmental Toxicity Test Methods
- News from Down Under: RSPCA Welcomes Planned Ban on Cosmetic Testing on Animals
Information Day on Progress in Alternative Methods in Toxicology and Biomedicine
July 8th, 2016
09:00 - 16:00
A think tank of the Doerenkamp-Zbinden Foundation and CAAT-Europe
Toxicology traditionally relies on the use of animals to derive information relevant for human well-being and safety. Today, human cell-based alternative methods have significantly advanced the testing process. Several animal tests have been substituted by animal-free methods for safety and quality testing. And increasingly, biomedical research uses more animal-free models alone or in combination with traditional animal tests.
The Doerenkamp-Zbinden Foundation (DZF), created in 1985 in Switzerland, and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), founded in 1981 in the US, are two of the most significant forces in the field of alternatives. The DZF has sponsored chairs for alternative methods in several countries. The chair at the University of Konstanz celebrates its 10th anniversary this year, and will now be continued by the federal state of Baden-Würrtemberg after its excellent performance evaluation.
This anniversary symposium is being organized to take stock of the dramatic changes the field has undergone during these last ten years, and to demonstrate the work of DZF chairs in the US, India, Switzerland, The Netherlands, and Konstanz.
Information & Registration: firstname.lastname@example.org
Full information and agenda may be found here
CAAT Academy Returns After the Summer with Two Sessions—Please Save the Date!
- Kidney toxicity testing and best practices
September 22-23, 2016, Vienna (AT) hosted by evercyte
- Current applications of organs-on-a-chip for the pharmaceutical industry
November 17-18, 2016, Leiden (NL) hosted by MIMETAS
SPACES ARE LIMITED. If you are interested in, please send an email to email@example.com
to receive the preliminary program.
CAAT's Mini-Brains Research Featured in Hopkins Bloomberg Public Health Magazine
Mini-Brains: The Rat Replacement
A human-derived model for neurological disease studies and drug development.
The human brain has a new mini-me, a tiny white bundle of cells no larger than a snowflake. The live replica can be used not only to study neurological diseases that plague populations but also to spare rats—saving millions of dollars annually on animal testing.
In drug development for brain diseases, “failure is notorious,” says Thomas Hartung, MD, PhD, director of the Center for Alternatives to Animal Testing. Rats are the easy go-to model for clinical experiments, he explains, but even when drug trials succeed in rats and progress to humans, 95 percent fail.
“We hope something more human will help,” says Hartung, who has gained widespread recognition for developing a mini-brain more complete in structure than an earlier prototype. Importantly, his technique has proven ideal for mass production.
Thomas Hartung Quoted in Article About TSCA
To hear proponents speak of it, an update to TSCA was a long time coming. Passed alongside a number of powerful environmental regulations like the Clean Air Act and the Clean Water Act, TSCA was originally passed to give the EPA the authority to assess the health risk of chemicals found on a litany of everyday objects, from toys to baking pans to household cleaners. In some cases, that worked—the agency decided that about 200 compounds were too risky because how they may act in the body.
But, largely, it didn’t. The TSCA inventory contains more than 80,000 chemicals (the exact figure grows almost daily), and yet the agency has data on a mere 3 percent of them, according to Thomas Hartung, an environmental health professor at the Johns Hopkins Bloomberg School of Public Health. “The vast majority of substances in consumer products have no data at all,” Hartung said. “That’s a situation that is simply not acceptable. These things go into everyday life.”
Full Article, Obama Grants EPA Power to Protect You From Being Poisoned, at Vocativ
ALTEX Impact Factor Rises to 5.824
The impact factor of ALTEX: Alternative to Animal Experimentation,
as reported by Thompson Reuters, has risen to 5.824. In the category "Medicine, Research, and Experimental Science" the journal ranked 11 of 124.
, edited by the Swiss Society ALTEX Edition, is the official journal of CAAT, EUSAAT (the European Society for Alternatives to Animal Testing), t4
, the Transatlantic Think Tank for Toxicology (Baltimore, Utrecht, Konstanz), and the Doerenkamp chairs in Germany, India, The Netherlands, Switzerland, and USA. ALTEX is devoted to the publication of research on the development and promotion of alternatives to animal experiments according to the 3Rs concept of Russell and Burch: Replace, Reduce,
The journal is available free, in its entirety, on Altweb
ALTEX Main Page
Video: Thomas Hartung on Promoting Dialogue Between In Vivo, In Vitro, and In Silica at the IRCS Institute for Pharmacological Research in Milan
Full presentation (in Italian) my be found here.
NICEATM Requests Data and Information on Developmental Toxicity Test Methods
In a Federal Register notice published today, NICEATM requested available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce adverse effects in offspring.
Respondents should provide information on any activities relevant to the development or validation of alternatives to in vivo developmental toxicity test methods currently required by regulatory agencies, including data from non-animal chemical tests for developmental hazard potential. NICEATM also requests any available data resulting from in vivo developmental studies, ethical human or animal studies, or accidental human exposures, using the same chemicals.
Please respond by August 15. More information is available on the NICEATM website
News from Down Under: RSPCA Welcomes Planned Ban on Cosmetic Testing on Animals
From the Sydney Morning Herald:
The RSPCA has welcomed a planned federal government ban on cosmetic products that have been tested on live animals, which could be in place from next year.
An estimated 27,000 animals are used for live testing every year around the world, prompting the proposed ban on cosmetics including perfumes, make-up and other common products.
Product ingredients that have undergone similar animal testing would also be banned.
While animal testing is not used for the production of cosmetics in Australia, there is currently no legislation banning companies from doing so. Australian stores still stock cosmetic products from overseas that have been tested on animals or contain ingredients tested on animals.
Best wishes from all of us,
The CAAT Team