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Updates from the Center for Alternatives to Animal Testing (CAAT)
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September 24, 2019

News and Updates from CAAT

   Contents:


Paul Locke: EPA's Bold Step Forward: Good for Animals and Science, Better for People

Op-ed by Paul Locke in The Hill
 
Excerpt:

The recent directive by the Environmental Protection Agency (EPA) that it will reduce, and eventually eliminate, animal testing by 2035 is an important, welcome and overdue action. It is based on scientific and policy advancements that have been in the works for many years. 

In 2007, the National Academy of Sciences, Engineering and Medicine (NASEM) issued the report Toxicity Testing in the 21st Century that recommended that EPA fundamentally change the way chemicals are tested. 

The report concluded that the EPA should move toward a testing system that is more human relevant, cost effective and much less reliant on animal toxicology. EPA’s focus should be on evaluating biological processes that can lead to diseases. 

To help make the vision of this report a reality, the federal government has invested in the underlying science. EPA launched a computational toxicology research program that includes high-throughput screening and robotics. 

The EPA, the Food and Drug Administration (FDA) and the National Institutes of Health (NIH) have created a program called “Tox21,” which applies 21st Century scientific tools to screen thousands of compounds for toxicity—without new animal tests. 

In addition research universities (including my own) are also working hard to implement this vision. We do not yet have a full suite of non-animal tests ready to go, but these efforts demonstrate that we are serious about moving forward. 

EPA’s decision correctly charts the arc of modern day regulatory toxicology while at the same time challenging the scientific community to do more. First, this move by the EPA is consistent with the concept of the three “Rs” of replacement, reduction and refinement, an idea about how to approach animal testing that was first proposed and adopted 60 years ago. 

The three Rs underlie U.S. laws, regulations and policies that govern the use of animals in laboratories.  One of these Rs, replacement, calls for the substitution of animal tests for non-animal methods when possible. The announcement by EPA is a bold step toward replacement, and in line with our scientific heritage. 

Seeking to reduce and eventually eliminate vertebrate animal testing is also consistent with the actions that Congress taken. Congressional desire to move in this direction is evident in recent legislation.

Paul A. Locke is an environmental health scientist and attorney. He is also an associate professor at Johns Hopkins Bloomberg School of Public Health in the Department of Environmental Health and Engineering.


Full article in The Hill
 
 


JHU Exposome Collaborative Launch Event

November 8, 2019
Johns Hopkins Bloomberg School of Public Health
Baltimore, Maryland

The Exposome Collaborative at Johns Hopkins was funded to congregate the intellectual and material resources housed under the various disciplines within the environmental health sciences and engineering, to evaluate the exposome in a holistic manner. The goals of The Exposome Collaborative at Johns Hopkins:

  • Develop the needed tools and analyses for exposome assessment.
  • Bring together expertise in all the different disciplines needed to better characterize the exposome in human health studies.

Program

12-1pm
Grand Rounds Speaker (Stephen Rappaport, PhD)

1-2:30pm
Lunch reception (open to all attendees)

1:30pm
Welcome announcement

2:30-2:45pm
Opening remarks

2:45-3pm
Introduction to JHU Exposome Collaborative

3-3:25pm
Exposome pilot project & data presentation

3:25-4:10pm
Speaker: Denis Sarigiannis, MS, PhD

4:10-4:55pm
Speaker: Gary Miller, MS, PhD

4:55-5pm
Concluding remarks

5-5:30pm
Celebratory toast

Information and Registration 
 




60 Years of the 3Rs: Lessons Learned & the Road Ahead

November 22, 2019
The Johns Hopkins Bloomberg School of Public Health
Baltimore, MD

Join us as we celebrate the 60th anniversary of the publication of The Principles of Humane Experimental Technique by W. M. S. Russell and R. L. Burch. 

Draft Agenda:

60 years of 3Rs: Lessons Learned

10 am – Opening Remarks - Andrew Rowan (Animal WellBeing International)
10:10 – 10:30 am - John Parascandola (National Library of Medicine, retired)
10:35 – 10:55 am -  Michael Balls (Fund for the Replacement of Animals in Medical Experiments) Rodger Curren
11:00 – 11:20 am - Alan Goldberg (CAAT) Michael Balls
11:25 – 11:45 am - Horst Spielmann (Free University of Berlin)
11:50 – 12:10 pm - Julia Fentem (Unilever)
12:10 – 12:30 pm - Rodger Curren (Institute for In Vitro Sciences)
1pm – 2 pm Lunch

CAAT’s Role in 3Rs for the 21st Century

2:05 – 2:20 pm - Martin Stephens (CAAT)
2:25 – 2:40 pm - Katya Tsaioun (EBTC)
2:45 – 3:00 pm - Kathrin Herrmann (CAAT)
3:05 – 3:20 pm - Thomas Hartung (CAAT)

Looking Forward: The Future with 3Rs

3:25 – 3:40 pm - Rusty Thomas (TBC) (Environmental Protection Agency)
3:45 – 4:00 pm - Chris Austin (TBC) (National Center for Advancing Translational Sciences)
4:05 – 4:20 pm - Don Ingber (TBC) (Harvard’s Wyss Institute for Biologically Inspired Engineering)

We will have an exciting roster of the biggest names in the history of alternatives, celebrating at the accomplishments of the past and forward to the breakthroughs of the future—look for details in an upcoming CAATwalk, but be sure to save the date now!

Information: https://tinyurl.com/3Rs60years

 


 


SAVE THE DATE!
7th Annual 3Rs Symposium: Practical Solutions and Success Stories

June 4-5, 2020
USDA National Agricultural Library
Beltsville, Maryland

The 7th Annual 3Rs symposium, co-hosted by the USDA Animal Welfare Information Center (AWIC), NIH Office of Laboratory Animal Welfare (OLAW), the Johns Hopkins Department of Molecular and Comparative Pathobiology, and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), will be held June 4-5, 2020 in Beltsville, Maryland. The goal of this year’s symposium is to bring together experts in replacement, reduction, and refinement of animal experimentation to exchange information with scientists, IACUC members, veterinarians, and animal care technicians about practical solutions and recent success stories to reduce the use of animals in research and improve their welfare.

The format includes 1.5 days of lectures and panel discussions with interactive breakout sessions in the afternoon on day two. These lectures give participants a strong foundation in the relevant research underlying breakthroughs in the 3Rs, while the breakout sessions allow participants to receive feedback specific to their own facilities from experts and colleagues. A half-day tour of labs and research centers at the Agricultural Research Service is planned for June 3, 2019 as an optional pre-symposium event.
 



5th International Conference on Developmental Neurotoxicity (DNT) Testing (DNT5)

April 6-8, 2020
Konstanz, Germany

The effects of chemical exposure on the susceptible developing human nervous system can cause severe lasting neurological deficits. 

This conference will bring together diverse stakeholders from around the globe, including research scientists, regulators, industry representatives, academics, and pediatricians to discuss the actions to take for: 

  • improving the development of time- efficient and human-relevant predictive in vitro DNT methods, and;
  • boosting their use in the risk assessment regulatory decision-making process.
Details

 




EUSAAT Congress 2019

October 10-13, 2019
Linz, Austria

The conference program is now available. 

Details and Registration
 
 

Accelerating the Transition Towards Animal-free Innovations

Pioneer-2-Policymaker Conference
November 27-29, 2019
Utrecht, The Netherlands

Details and Registration
 


Final OpenRiskNet Workshop: Creating Powerful Workflows Combining Data and Software Services Demonstrated on Risk Assessment Case Studies

Workshop (organized by OpenRiskNet)
October 23-24, 2019
Amsterdam

Details and Registration
 

11th World Congress on Alternatives and Animal Use in the Life Sciences 2020 (WC11)

Stay updated via the official website www.wc11maastricht.org and subscribe to the official WC11 newsletter for important news and developments.

 



Best wishes from all of us,

The CAAT Team

     

hand holding centrifuge tubes

Upcoming Events
 

 
ALTERTOX Academy Training:
PBPK Modeling and Quantitative In Vitro-In Vivo Extrapolation
October 3-4, 2019
Wageningen, Netherlands

Linz 2019/EUSAAT 2019
October 10-13, 2019
Linz, Austria

ALTERTOX Academy Training:
Novel In Silico Models for Assessment of Cosmetics
October 17-18, 2019
Milan, Italy

Final OpenRiskNet Workshop: Creating Powerful Workflows Combining Data and Software Services Demonstrated on Risk Assessment Case StudiesWorkshop
October 23-24, 2019
Amsterdam

ALTERTOX Academy Training:
Good In Vitro Methods in Practice
November 6-7, 2019
Gothenburg, Sweden

JHU Exposome Collaborative Launch Event
November 8, 2019
Baltimore, Maryland

ALTERTOX Academy Training:
In Vitro Lung Models
November 14-15, 2019
Geneva, Switzerland

ALTERTOX Academy Training:
Acute and Chronic Cardiotoxicity: CiPA (In Silico & In Vitro) Assays
November 14-15, 2019
Leiden, The Netherlands

ACT 2019 Annual Meeting
November 17-20, 2019
Phoenix, Arizona

ALTERTOX Academy Training:
Irritation Oculaire In Vitro
November 21, 2019
Lyon, France

ALTERTOX Academy Training:
Skin Sensitization
November 21-22, 2019
Trier, Germany

SAVE THE DATE!
60 Years of the 3Rs: Lessons Learned & the Road Ahead
November 22, 2019
Baltimore, MD

Accelerating the Transition Towards Animal-free Innovations
November 27-29, 2019
Utrecht, The Netherlands
 
Practical Methods for In Vitro Toxicology
January 13-16, 2020
Gaithersburg, MD

ESTIV Applied In Vitro Training Course
April 5-10, 2020
Brussels

5th International Conference on Alternatives for Developmental Neurotoxicity (DNT) Testing
April 6-8, 2020
Konstanz, Germany

SAVE THE DATE!
3Rs Symposium: Practical Solutions and Success Stories
June 4-5, 2020
USDA National Agricultural Library
Washington, DC

QSAR 2020: From QSAR to New Approach Methodologies
June 8-10, 2020
Durham, NC

ESTIV 2020
June 8-11, 2020
Barcelona
 
 
Full Listing of CAAT Programs
and Activities

 

 

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