Op-ed by Paul Locke in The Hill
Paul Locke: EPA's Bold Step Forward: Good for Animals and Science, Better for People
The recent directive by the Environmental Protection Agency (EPA) that it will reduce, and eventually eliminate, animal testing by 2035 is an important, welcome and overdue action. It is based on scientific and policy advancements that have been in the works for many years.
In 2007, the National Academy of Sciences, Engineering and Medicine (NASEM) issued the report Toxicity Testing in the 21st Century that recommended that EPA fundamentally change the way chemicals are tested.
The report concluded that the EPA should move toward a testing system that is more human relevant, cost effective and much less reliant on animal toxicology. EPA’s focus should be on evaluating biological processes that can lead to diseases.
To help make the vision of this report a reality, the federal government has invested in the underlying science. EPA launched a computational toxicology research program that includes high-throughput screening and robotics.
The EPA, the Food and Drug Administration (FDA) and the National Institutes of Health (NIH) have created a program called “Tox21,” which applies 21st Century scientific tools to screen thousands of compounds for toxicity—without new animal tests.
In addition research universities (including my own) are also working hard to implement this vision. We do not yet have a full suite of non-animal tests ready to go, but these efforts demonstrate that we are serious about moving forward.
EPA’s decision correctly charts the arc of modern day regulatory toxicology while at the same time challenging the scientific community to do more. First, this move by the EPA is consistent with the concept of the three “Rs” of replacement, reduction and refinement, an idea about how to approach animal testing that was first proposed and adopted 60 years ago.
The three Rs underlie U.S. laws, regulations and policies that govern the use of animals in laboratories. One of these Rs, replacement, calls for the substitution of animal tests for non-animal methods when possible. The announcement by EPA is a bold step toward replacement, and in line with our scientific heritage.
Seeking to reduce and eventually eliminate vertebrate animal testing is also consistent with the actions that Congress taken. Congressional desire to move in this direction is evident in recent legislation.
Full article in The Hill
Paul A. Locke is an environmental health scientist and attorney. He is also an associate professor at Johns Hopkins Bloomberg School of Public Health in the Department of Environmental Health and Engineering.
JHU Exposome Collaborative Launch Event
November 8, 2019
Johns Hopkins Bloomberg School of Public Health
The Exposome Collaborative at Johns Hopkins was funded to congregate the intellectual and material resources housed under the various disciplines within the environmental health sciences and engineering, to evaluate the exposome in a holistic manner. The goals of The Exposome Collaborative at Johns Hopkins:
- Develop the needed tools and analyses for exposome assessment.
- Bring together expertise in all the different disciplines needed to better characterize the exposome in human health studies.
Grand Rounds Speaker (Stephen Rappaport, PhD)
Lunch reception (open to all attendees)
Introduction to JHU Exposome Collaborative
Exposome pilot project & data presentation
Speaker: Denis Sarigiannis, MS, PhD
Speaker: Gary Miller, MS, PhD
Information and Registration
60 Years of the 3Rs: Lessons Learned & the Road Ahead
November 22, 2019
The Johns Hopkins Bloomberg School of Public Health
Join us as we celebrate the 60th anniversary of the publication of The Principles of Humane Experimental Technique
by W. M. S. Russell and R. L. Burch.
60 years of 3Rs: Lessons Learned
10 am – Opening Remarks - Andrew Rowan (Animal WellBeing International)
10:10 – 10:30 am - John Parascandola (National Library of Medicine, retired)
10:35 – 10:55 am - Michael Balls (Fund for the Replacement of Animals in Medical Experiments) Rodger Curren
11:00 – 11:20 am - Alan Goldberg (CAAT) Michael Balls
11:25 – 11:45 am - Horst Spielmann (Free University of Berlin)
11:50 – 12:10 pm - Julia Fentem (Unilever)
12:10 – 12:30 pm - Rodger Curren (Institute for In Vitro Sciences)
1pm – 2 pm Lunch
CAAT’s Role in 3Rs for the 21st Century
2:05 – 2:20 pm - Martin Stephens (CAAT)
2:25 – 2:40 pm - Katya Tsaioun (EBTC)
2:45 – 3:00 pm - Kathrin Herrmann (CAAT)
3:05 – 3:20 pm - Thomas Hartung (CAAT)
Looking Forward: The Future with 3Rs
3:25 – 3:40 pm - Rusty Thomas (TBC) (Environmental Protection Agency)
3:45 – 4:00 pm - Chris Austin (TBC) (National Center for Advancing Translational Sciences)
4:05 – 4:20 pm - Don Ingber (TBC) (Harvard’s Wyss Institute for Biologically Inspired Engineering)
We will have an exciting roster of the biggest names in the history of alternatives, celebrating at the accomplishments of the past and forward to the breakthroughs of the future—look for details in an upcoming CAATwalk, but be sure to save the date now!
SAVE THE DATE!
7th Annual 3Rs Symposium: Practical Solutions and Success Stories
June 4-5, 2020
USDA National Agricultural Library
Annual 3Rs symposium, co-hosted by the USDA Animal Welfare Information Center (AWIC), NIH Office of Laboratory Animal Welfare (OLAW), the Johns Hopkins Department of Molecular and Comparative Pathobiology, and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), will be held June 4-5, 2020 in Beltsville, Maryland. The goal of this year’s symposium is to bring together experts in replacement, reduction, and refinement of animal experimentation to exchange information with scientists, IACUC members, veterinarians, and animal care technicians about practical solutions and recent success stories to reduce the use of animals in research and improve their welfare.
The format includes 1.5 days of lectures and panel discussions with interactive breakout sessions in the afternoon on day two. These lectures give participants a strong foundation in the relevant research underlying breakthroughs in the 3Rs, while the breakout sessions allow participants to receive feedback specific to their own facilities from experts and colleagues. A half-day tour of labs and research centers at the Agricultural Research Service is planned for June 3, 2019 as an optional pre-symposium event.
5th International Conference on Developmental Neurotoxicity (DNT) Testing (DNT5)
April 6-8, 2020
The effects of chemical exposure on the susceptible developing human nervous system can cause severe lasting neurological deficits.
This conference will bring together diverse stakeholders from around the globe, including research scientists, regulators, industry representatives, academics, and pediatricians to discuss the actions to take for:
- improving the development of time- efficient and human-relevant predictive in vitro DNT methods, and;
- boosting their use in the risk assessment regulatory decision-making process.
EUSAAT Congress 2019
October 10-13, 2019
The conference program
is now available.
Details and Registration
Accelerating the Transition Towards Animal-free Innovations
Details and Registration
November 27-29, 2019
Utrecht, The Netherlands
Final OpenRiskNet Workshop: Creating Powerful Workflows Combining Data and Software Services Demonstrated on Risk Assessment Case Studies
Workshop (organized by OpenRiskNet)
Details and Registration
October 23-24, 2019
11th World Congress on Alternatives and Animal Use in the Life Sciences 2020 (WC11)
Stay updated via the official website www.wc11maastricht.org and subscribe to the official WC11 newsletter for important news and developments.
Best wishes from all of us,
The CAAT Team