Updates from the Center for Alternatives to Animal Testing (CAAT)
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November 8, 2017

News and Updates from CAAT

In This Issue:


New ALTEX Volume 34, No. 4 Now Online

The latest issue of ALTEX: Alternatives to Animal Experimentation is now online in its entirety. This issue includes:

Thomas Luechtefeld and Thomas Hartung
Computational approaches to chemical hazard assessment 

t4 Workshop Report
Dayna Kerecman Myers, Alan M. Goldberg, Albrecht Poth, Michael F. Wolf, Joseph Carraway, James McKim, Kelly P. Coleman, Richard Hutchinson, Ronald Brown, Harald F. Krug, Anthony Bahinski and Thomas Hartung 
From in vivo to in vitro: The medical device testing paradigm shift

Ans Punt, Ad A. C. M. Peijnenburg, Ron L. A. P. Hoogenboom and Hans Bouwmeester
Non-animal approaches for toxicokinetics in risk evaluations of food chemicals

Henrik Johansson, Robin Gradin, Andy Forreryd, Maria Agemark, Kathrin Zeller, Angelica Johansson, Olivia Larne, Erwin van Vliet, Carl Borrebaeck and Malin Lindstedt
Evaluation of the GARD assay in a blind Cosmetics Europe study

Maria Leontaridou, Daniel Urbisch, Susanne N. Kolle, Katharina Ott, Denis S. Mulliner, Silke Gabbert and Robert Landsiedel
The borderline range of toxicological methods: Quantification and implications for evaluating precision

Along with much more, including alternatives news from around the globe. 

ALTEX 34/4 Full Text

REGISTER NOW: Progress in Refinement: Enhancement of Scientific Integrity and Animal Well-Being
November 30th
Johns Hopkins Bloomberg School of Public Health, Baltimore

This one-day symposium focusing on refinement will include discussions on social housing, pain assessment and management, environmental enrichment, and other critical topics.

The event will conclude with a retirement reception honoring Joanne Zurlo, CAAT's Director of Science Strategy and head of the Refinement program. 

Draft Agenda


Keynote: Why Refinement Matters
Marilyn Brown

Major Advances in Refinement

  • Social Housing
    Pat Brown
  • Pain Assessment/Management
    Norman Peterson
  • Environmental Enrichment
    Karen Froberg-Fejko


Major Advances in Refinement (cont'd)

  • Noninvasive imaging
    Kathy Gabrielson and Joe Mankowski
  • Science of Animal Welfare
    Eric Hutchinson
  • Scientific Implications for Rigor and Reproducibility
    Kelly Pate and Melanie Graham


Science-based Refinement Award Program Awardees

  • Debra Hickman
  • Cathy Schuppli

Final Discussion on Future Refinement at CAAT
Joanne Zurlo and Kathrin Herrmann

Reception and Retirement Celebration for Joanne Zurlo

Registration and Information


Next Generation Humane Science Award

Deadline for Applications: November 30, 2017

The Next Generation Humane Science Award is available annually to young scientists in the US to acknowledge and encourage researchers who focus on replacing the use of animals in experiments. 
The 2017 award will be a prize of up to $9,000 to recognize the work of one young scientist, or may be shared among two or more young scientists. Applications are due no later than November 30, 2017.
For information and application form, please visit:


Upcoming: Non-Human Primates, Biomedical Research, New Technologies, and Replacement Methods
November 9, 2017

CAAT's Thomas Hartung and Costanza Rovida will be presenting at this conference sponsored by Italian Senator Silvana Amato in collaboration with OSA (Oltre la Sperimentazione Animale (Beyond Experiments with Animals) and LAV (Italian Anti-Vivisection League). Hartung will discuss "New Animal-free Strategies for Product Safety." Details and Registration


CAAT and CAAT Academy Workshop in Turkey on 3Rs & 2D, 3D Liver, Skin, Eye and Gastrointestinal Regulatory Models 

On November 1st, CAAT and CAAT Academy organized a workshop on 3Rs & 2D, 3D Liver, Skin, Eye and Gastrointestinal Regulatory Models at the Tubitak MAM Research Centre in Turkey. About 100 people attended the events.

Turkey has already legally implemented the principles of Directive EC 2010/63, and is committed to establishing a formal 3Rs center for the dissemination and validation of implementation of new alternative methods. The following day, 25 students had the opportunity to learn in the lab with practical experiments using reconstructed human epidermal, in vitro-cornea models, and 3D primary human intestine. Special focus was also dedicated to in vitro models for drug hepatotoxicity. 

Thomas Hartung on New Technologies Driving the Future of Healthcare and Public Health at World Science Forum 2017

CAAT Director Thomas Hartung will speak at the World Science Forum 2017 at the King Hussein Bin Talal Convention Centre in Jordan on November 10th. Hartung's talk, "New Technologies Driving the Future of Healthcare and Public Health," is part of a session on sustainable development goals. 

World Science Forum 2017


Recent Publications

Harris G, Hogberg H, Hartung T and Smirnova L. 3D differentiation of LUHMES cell line to study recovery and delayed neurotoxic effects. Current Protocols in Toxicology 2017, 73, 11.23.1–11.23.28. doi: 10.1002/cptx.29.

Hartung T and Rovida C. Prospettive della ricerca scientifica attraverso metodi alternative alla sperimentazione animale. In: Ferroni MV and Campanaro C. (Ed). Metodi alternative alla sperimentazione animale. G. Giappichelli Editore, Torino, 17-23. 

Maertens A and Hartung T. Green toxicology – know early about and avoid toxic product liabilities. Toxicol. Sci. 2017, in press.

NC3Rs International £30k 3Rs Prize

Each year the NC3Rs awards a prize, sponsored by GlaxoSmithKline, to highlight an outstanding original contribution to scientific and technological advances in the 3Rs, published in the last three years. The award consists of a £28k prize grant and £2k personal award. Highly-commended entries receive a £4k grant and a £1k personal award.

This year's competition is now open for applications with a deadline of 4pm (GMT) on Monday 4 December 2017.

For further information on the 3Rs prize, please contact or visit:

Interested in improving health through toxicology?
Study Environmental Health Sciences Johns Hopkins!

Best wishes from all of us,

The CAAT Team
hand holding centrifuge tubes

Upcoming Events

Non-Human Primates, Biomedical Research, New Technologies, and Replacement Methods
November 9, 2017

World Science Forum 2017
November 7-11, 2017
King Hussein Bin Talal Convention Centre, Dead Sea

CAAT Academy - Epithelix
November 16-17, 2017
In Vitro Lung Models
Geneva, Switzerland

November 16-17, 2017
Current Applications of Organs-on-a-Chip for the Pharmaceutical Industry
Leiden, The Netherlands

OpenTox Euro 2017
November 22-23, 2017

Progress in Refinement: Enhancement of Scientific Integrity and Animal Well-Being
November 30, 2107

GIVIMP and Quality Procedures for the EU-ToxRisk Project (Webinar)
December 1, 2017
Details TBA

20th International Congress on In Vitro Toxicology (ESTIV2018)
October 15-18, 2018

Full Listing of CAAT Programs
and Activities

Altweb Calendar of Events


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