News and Updates from CAAT
JHU Exposome Collaborative Launch Event
November 8, 2019
Johns Hopkins Bloomberg School of Public Health
The Exposome Collaborative at Johns Hopkins was funded to congregate the intellectual and material resources housed under the various disciplines within the environmental health sciences and engineering, to evaluate the exposome in a holistic manner. The goals of The Exposome Collaborative at Johns Hopkins:
- Develop the needed tools and analyses for exposome assessment.
- Bring together expertise in all the different disciplines needed to better characterize the exposome in human health studies.
Grand Rounds Speaker (Stephen Rappaport, PhD, Berkeley Public Health)
Lunch reception (open to all attendees)
Introduction to JHU Exposome Collaborative
Exposome pilot project & data presentation
Speaker: Denis Sarigiannis, MS, PhD (Aristotle University of Thessaloniki)
Speaker: Gary Miller, MS, PhD (Columbia Mailman School of Public Health)
Information and Registration
New Speakers Added! Updated Agenda!
60 Years of the 3Rs: Lessons Learned & the Road Ahead
November 22, 2019
The Johns Hopkins Bloomberg School of Public Health
Join us as we celebrate the 60th anniversary of the publication of The Principles of Humane Experimental Technique
by W. M. S. Russell and R. L. Burch.
Nicole Kleinstreuer (NIEHS) and Rusty Thomas (EPA), two champions of the new generation in the 3Rs and CAAT board members, have joined as speakers for the "Looking Forward" segment of the event.
60 years of 3Rs: Lessons Learned
- 10am – Opening Remarks - Andrew Rowan (Animal WellBeing International)
- 10:20 – 10:40am - John Parascandola (National Library of Medicine, retired)
- 10:45 – 11:05am - Michael Balls (Fund for the Replacement of Animals in Medical Experiments)
- 11:10 – 11:30am - Alan Goldberg (CAAT)
- 11:35 – 11:55am - Horst Spielmann (Free University of Berlin)
- 12:00 – 12:20pm - Julia Fentem (Unilever)
- 12:10 – 12:3 pm - Rodger Curren (Institute for In Vitro Sciences)
- 1pm – 2pm Lunch
Looking Forward: The Future of the 3Rs and CAAT's Role in the 21st Century
- 2:05 – 2:20pm - Nicole Kleinstreuer (National Institute of Environmental Health Sciences, NICEATM Deputy Director)
- 2:25 – 2:40pm - Katya Tsaioun (EBTC)
- 2:45 – 3:00pm - Kathrin Herrmann (CAAT)
- 3:05 – 3:20pm - Thomas Hartung (CAAT)
- 3:25 – 3:40pm - Rusty Thomas (EPA)
- 3:45 – 4:00pm - Martin Stephens (CAAT)
Gold Level $2,500: Foundation for Chemistry Research and Initiatives, Alternatives Research & Development Foundation (ARDF), The American Cleaning Institute (ACI)
Silver Level $1,000: International Fragrance Association (IFRA), Institute for In Vitro Sciences (IIVS), John “Jack” R. Fowle III
To become a sponsor, contact us!
Full Information and Registration: https://tinyurl.com/3Rs60years
SAVE THE DATE!
7th Annual 3Rs Symposium: Practical Solutions and Success Stories
June 4-5, 2020
USDA National Agricultural Library
Annual 3Rs symposium, co-hosted by the USDA Animal Welfare Information Center (AWIC), NIH Office of Laboratory Animal Welfare (OLAW), the Johns Hopkins Department of Molecular and Comparative Pathobiology, and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), will be held June 4-5, 2020 in Beltsville, Maryland. The goal of this year’s symposium is to bring together experts in replacement, reduction, and refinement of animal experimentation to exchange information with scientists, IACUC members, veterinarians, and animal care technicians about practical solutions and recent success stories to reduce the use of animals in research and improve their welfare.
The format includes 1.5 days of lectures and panel discussions with interactive breakout sessions in the afternoon on day two. These lectures give participants a strong foundation in the relevant research underlying breakthroughs in the 3Rs, while the breakout sessions allow participants to receive feedback specific to their own facilities from experts and colleagues. A half-day tour of labs and research centers at the Agricultural Research Service is planned for June 3, 2019 as an optional pre-symposium event.
5th International Conference on Developmental Neurotoxicity (DNT) Testing (DNT5)
April 6-8, 2020
The effects of chemical exposure on the susceptible developing human nervous system can cause severe lasting neurological deficits.
This conference will bring together diverse stakeholders from around the globe, including research scientists, regulators, industry representatives, academics, and pediatricians to discuss the actions to take for:
- improving the development of time- efficient and human-relevant predictive in vitro DNT methods, and;
- boosting their use in the risk assessment regulatory decision-making process.
Summer School on Innovative Approaches in Science
June 22-25, 2020
Calling all students and early-career scientists interested in innovative approaches in toxicology and biomedical sciences
In response to a growing need to be conversant in innovative approaches in toxicology and biomedical sciences, this summer school will share knowledge and experience with a new generation of scientists on research and testing methods. The program will highlight modern alternatives to the use of animals—including in vitro and computational modeling—in toxicology and biomedical sciences. The state of scientific research will be explored through lectures and discussion.
The Summer School will be separated into two tracks: toxicology and biomedical science. The program will combine lectures from experts in the field of toxicology and biomedical science with interactive sessions to encourage discussion and facilitate networking among participants.
This program will offer:
- Modern alternatives to the use of animals in toxicology and biomedical sciences
- Diverse presentations from all major stakeholders
- Platform, poster, and networking sessions
- Welcome and networking reception dinners
- Laboratory visits
- Travel awards and more
Details and Registration
- Luciene Balottin, Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil
- Kambez H. Benam, University of Colorado School of Medicine
- Elisabet Berggren, European Commission Joint Research Centre
- Warren Casey, National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institutes of Health
- Charu Chandrasekera, Canadian Centre for Alternatives to Animal Methods
- Maureen R. Gwinn, Environmental Protection Agency
- Thomas Hartung, Johns Hopkins University Center for Alternatives to Animal Testing
- Esther Haugabrooks, Physicians Committee for Responsible Medicine
- Kathrin Herrmann, Johns Hopkins University Center for Alternatives to Animal Testing
- Erin Hill, Institute for In Vitro Sciences
- Tara Barton-Maclaren, Health Canada
- Janine McCarthy, Physicians Committee for Responsible Medicine
- Jason O’Brien, Environment and Climate Change Canada
- Kathryn Page, Clorox Company
- Louis Scarano, Environmental Protection Agency
- Martin Stephens, Johns Hopkins University Center for Alternatives to Animal Testing
- Kristie Sullivan, Physicians Committee for Responsible Medicine
- Maurice Whelan, European Commission Joint Research Centre
Excerpt from Nature (October 2019):
CAAT in Nature: India Pushes for Alternatives to Animals in Biomedical Research
Some researchers think there are alternative technologies that are good enough to switch away from animal testing, at least for researching toxicity. “The value of animal testing is strongly overestimated,” says Thomas Hartung, director of the Center for Alternatives to Animal Testing at Johns Hopkins University in Baltimore, Maryland. Hartung has developed an algorithm as an alternative to animal testing that has successfully predicted the toxicity of tens of thousands of chemicals in human tissue—and in some cases has outperformed animal tests in terms of reliability. “Whenever an animal test has been systematically evaluated, the outcome was astonishingly poor,” he says.
Full article in Nature
Thomas Hartung Interviewed for Department of Health and Human Services Report: Federal Agencies Should Assess and Report on Their Efforts to Develop and Promote Alternatives
Researchers often use animals to study disease, test product safety, experiment, or teach. Some uses cause animals pain or distress. Federal agencies require researchers to consider alternatives to animal use, such as computer modeling or working with cell cultures.
The Department of Health and Human Services and other agencies have developed animal use alternatives and collaborate on these efforts in an interagency group. However, the agencies don’t routinely measure the effect of those efforts. We recommended that HHS create a workgroup to help agencies assess and report on their progress in reducing or replacing animal use in research.
Read the Full Report
Moving Beyond the Three Rs in Biomedical Research
Recent paper by Kathrin Herrmann, Francesca Pistollato, and Martin L. Stephens Profiled at EU Science Hub
A new study co-authored by the JRC prioritizes human relevant methods and the replacement of animal models in biomedical research. Read the discussion here.
Vy Tran, Student at CAAT, Wins Tox21 Student Award
Vy Tran, a student at CAAT, received the Tox21 Student Award for her project “Comparing gene networks between MCF-7 cell line and human breast cancer.” Dr. Ray Tice, a leader in the development and use of high-throughput test methods and other alternatives, established the Tox21 Student Award, which will be awarded to the graduate student first author of a winning poster or oral presentation. The winner receives a $500 cash award to assist with travel and/or research expenses.
More information about the conference and award can be found here.
Altertox Newsletter: New Team Member and Upcoming Training and Events
After a great EUROTOX poster presentation with high-quality interaction, we continue our tour at EUSAAT. It will be an opportunity to meet our new colleague Valentin who will present our poster while I will give a talk on safety data access.
This week also starts the last part of our training season for 2019 with kick-off at WUR where the whole Altertox team will be there!
Our motto #makebetterscience will continue:
Visit Altertox Academy
and sign up for the newsletter here
New EPA Plan to Reduce Animal Testing Will Protect Animals, the Environment, and Taxpayers (The Hill)
It’s worth noting how bipartisan and widely-appealing these efforts have always been, even in otherwise politically divided times. Three-quarters of Americans want to end animal testing. It’s been a pleasure over the years to work with diverse stakeholders ranging from the American Chemical Society, to the Johns Hopkins Bloomberg School of Public Health, to the animal-testing watchdog group White Coat Waste Project.
I applaud the EPA for recognizing that we can protect animals, the environment and taxpayers by sending animal testing to the trash bin of history.
from The Hill by Rep. Ken Calvert (R-California)
Abstract Submissions and Registration for the 21st Congress of the European Society of Toxicology In Vitro Now Open
June 8-11, 2020
Details and Registration
11th World Congress on Alternatives and Animal Use in the Life Sciences 2020 (WC11)
Stay updated via the official website www.wc11maastricht.org and subscribe to the official WC11 newsletter for important news and developments.
Best wishes from all of us,
The CAAT Team