Updates from the Center for Alternatives to Animal Testing (CAAT)
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October 11, 2019

News and Updates from CAAT


JHU Exposome Collaborative Launch Event

November 8, 2019
Johns Hopkins Bloomberg School of Public Health
Baltimore, Maryland

The Exposome Collaborative at Johns Hopkins was funded to congregate the intellectual and material resources housed under the various disciplines within the environmental health sciences and engineering, to evaluate the exposome in a holistic manner. The goals of The Exposome Collaborative at Johns Hopkins:

  • Develop the needed tools and analyses for exposome assessment.
  • Bring together expertise in all the different disciplines needed to better characterize the exposome in human health studies.


  • 12-1pm
    Grand Rounds Speaker (Stephen Rappaport, PhD, Berkeley Public Health)
  • 1-2:30pm
    Lunch reception (open to all attendees)
  • 1:30pm
    Welcome announcement
  • 2:30-2:45pm
    Opening remarks
  • 2:45-3pm
    Introduction to JHU Exposome Collaborative
  • 3-3:25pm
    Exposome pilot project & data presentation
  • 3:25-4:10pm
    Speaker: Denis Sarigiannis, MS, PhD (Aristotle University of Thessaloniki)
  • 4:10-4:55pm
    Speaker: Gary Miller, MS, PhD (Columbia Mailman School of Public Health)
  • 4:55-5pm
    Concluding remarks
  • 5-5:30pm
    Celebratory toast

Information and Registration 

New Speakers Added! Updated Agenda!
60 Years of the 3Rs: Lessons Learned & the Road Ahead

November 22, 2019
The Johns Hopkins Bloomberg School of Public Health
Baltimore, MD

Join us as we celebrate the 60th anniversary of the publication of The Principles of Humane Experimental Technique by W. M. S. Russell and R. L. Burch. 

Nicole Kleinstreuer (NIEHS) and Rusty Thomas (EPA), two champions of the new generation in the 3Rs and CAAT board members, have joined as speakers for the "Looking Forward" segment of the event.

Draft Agenda:

60 years of 3Rs: Lessons Learned

  • 10am – Opening Remarks - Andrew Rowan (Animal WellBeing International)
  • 10:20 – 10:40am - John Parascandola (National Library of Medicine, retired)
  • 10:45 – 11:05am -  Michael Balls (Fund for the Replacement of Animals in Medical Experiments)
  • 11:10 – 11:30am - Alan Goldberg (CAAT) 
  • 11:35 – 11:55am - Horst Spielmann (Free University of Berlin)
  • 12:00 – 12:20pm - Julia Fentem (Unilever)
  • 12:10 – 12:3 pm - Rodger Curren (Institute for In Vitro Sciences)
  • 1pm – 2pm Lunch

Looking Forward: The Future of the 3Rs and CAAT's Role in the 21st Century

  • 2:05 – 2:20pm - Nicole Kleinstreuer (National Institute of Environmental Health Sciences, NICEATM Deputy Director)
  • 2:25 – 2:40pm - Katya Tsaioun (EBTC)
  • 2:45 – 3:00pm - Kathrin Herrmann (CAAT)
  • 3:05 – 3:20pm - Thomas Hartung (CAAT)
  • 3:25 – 3:40pm - Rusty Thomas (EPA)
  • 3:45 – 4:00pm - Martin Stephens (CAAT)

Gold Level $2,500: Foundation for Chemistry Research and Initiatives, Alternatives Research & Development Foundation (ARDF), The American Cleaning Institute (ACI)

Silver Level $1,000: International Fragrance Association (IFRA), Institute for In Vitro Sciences (IIVS), John “Jack” R. Fowle III

To become a sponsor, contact us!

Full Information and Registration:



7th Annual 3Rs Symposium: Practical Solutions and Success Stories

June 4-5, 2020
USDA National Agricultural Library
Beltsville, Maryland

The 7th Annual 3Rs symposium, co-hosted by the USDA Animal Welfare Information Center (AWIC), NIH Office of Laboratory Animal Welfare (OLAW), the Johns Hopkins Department of Molecular and Comparative Pathobiology, and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), will be held June 4-5, 2020 in Beltsville, Maryland. The goal of this year’s symposium is to bring together experts in replacement, reduction, and refinement of animal experimentation to exchange information with scientists, IACUC members, veterinarians, and animal care technicians about practical solutions and recent success stories to reduce the use of animals in research and improve their welfare.

The format includes 1.5 days of lectures and panel discussions with interactive breakout sessions in the afternoon on day two. These lectures give participants a strong foundation in the relevant research underlying breakthroughs in the 3Rs, while the breakout sessions allow participants to receive feedback specific to their own facilities from experts and colleagues. A half-day tour of labs and research centers at the Agricultural Research Service is planned for June 3, 2019 as an optional pre-symposium event.

5th International Conference on Developmental Neurotoxicity (DNT) Testing (DNT5)

April 6-8, 2020
Konstanz, Germany

The effects of chemical exposure on the susceptible developing human nervous system can cause severe lasting neurological deficits. 

This conference will bring together diverse stakeholders from around the globe, including research scientists, regulators, industry representatives, academics, and pediatricians to discuss the actions to take for: 

  • improving the development of time- efficient and human-relevant predictive in vitro DNT methods, and;
  • boosting their use in the risk assessment regulatory decision-making process.


Summer School on Innovative Approaches in Science

June 22-25, 2020

Calling all students and early-career scientists interested in innovative approaches in toxicology and biomedical sciences

In response to a growing need to be conversant in innovative approaches in toxicology and biomedical sciences, this summer school will share knowledge and experience with a new generation of scientists on research and testing methods. The program will highlight modern alternatives to the use of animals—including in vitro and computational modeling—in toxicology and biomedical sciences. The state of scientific research will be explored through lectures and discussion.

The Summer School will be separated into two tracks: toxicology and biomedical science. The program will combine lectures from experts in the field of toxicology and biomedical science with interactive sessions to encourage discussion and facilitate networking among participants.

This program will offer: 

  • Modern alternatives to the use of animals in toxicology and biomedical sciences 
  • Diverse presentations from all major stakeholders
  • Platform, poster, and networking sessions
  • Welcome and networking reception dinners 
  • Laboratory visits 
  • Travel awards and more
Organizing Committee
  • Luciene Balottin, Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil
  • Kambez H. Benam, University of Colorado School of Medicine  
  • Elisabet Berggren, European Commission Joint Research Centre
  • Warren Casey, National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institutes of Health
  • Charu Chandrasekera, Canadian Centre for Alternatives to Animal Methods
  • Maureen R. Gwinn, Environmental Protection Agency
  • Thomas Hartung, Johns Hopkins University Center for Alternatives to Animal Testing
  • Esther Haugabrooks, Physicians Committee for Responsible Medicine
  • Kathrin Herrmann, Johns Hopkins University Center for Alternatives to Animal Testing
  • Erin Hill, Institute for In Vitro Sciences 
  • Tara Barton-Maclaren, Health Canada
  • Janine McCarthy, Physicians Committee for Responsible Medicine
  • Jason O’Brien, Environment and Climate Change Canada
  • Kathryn Page, Clorox Company
  • Louis Scarano, Environmental Protection Agency
  • Martin Stephens, Johns Hopkins University Center for Alternatives to Animal Testing
  • Kristie Sullivan, Physicians Committee for Responsible Medicine
  • Maurice Whelan, European Commission Joint Research Centre
Details and Registration

CAAT in Nature: India Pushes for Alternatives to Animals in Biomedical Research

Excerpt from Nature (October 2019):

Some researchers think there are alternative technologies that are good enough to switch away from animal testing, at least for researching toxicity. “The value of animal testing is strongly overestimated,” says Thomas Hartung, director of the Center for Alternatives to Animal Testing at Johns Hopkins University in Baltimore, Maryland. Hartung has developed an algorithm as an alternative to animal testing that has successfully predicted the toxicity of tens of thousands of chemicals in human tissue—and in some cases has outperformed animal tests in terms of reliability. “Whenever an animal test has been systematically evaluated, the outcome was astonishingly poor,” he says.

Full article in Nature

Thomas Hartung Interviewed for Department of Health and Human Services Report: Federal Agencies Should Assess and Report on Their Efforts to Develop and Promote Alternatives

Researchers often use animals to study disease, test product safety, experiment, or teach. Some uses cause animals pain or distress. Federal agencies require researchers to consider alternatives to animal use, such as computer modeling or working with cell cultures.

The Department of Health and Human Services and other agencies have developed animal use alternatives and collaborate on these efforts in an interagency group. However, the agencies don’t routinely measure the effect of those efforts. We recommended that HHS create a workgroup to help agencies assess and report on their progress in reducing or replacing animal use in research.

Read the Full Report


Moving Beyond the Three Rs in Biomedical Research

Recent paper by Kathrin Herrmann, Francesca Pistollato, and Martin L. Stephens Profiled at EU Science Hub

A new study co-authored by the JRC prioritizes human relevant methods and the replacement of animal models in biomedical research. Read the discussion here

Vy Tran, Student at CAAT, Wins Tox21 Student Award


Vy Tran, a student at CAAT, received the Tox21 Student Award for her project “Comparing gene networks between MCF-7 cell line and human breast cancer.” Dr. Ray Tice, a leader in the development and use of high-throughput test methods and other alternatives, established the Tox21 Student Award, which will be awarded to the graduate student first author of a winning poster or oral presentation. The winner receives a $500 cash award to assist with travel and/or research expenses.

More information about the conference and award can be found here.


Altertox Newsletter: New Team Member and Upcoming Training and Events


After a great EUROTOX poster presentation with high-quality interaction, we continue our tour at EUSAAT. It will be an opportunity to meet our new colleague Valentin who will present our poster while I will give a  talk on safety data access. 

This week also starts the last part of our training season for 2019 with kick-off at WUR where the whole Altertox team will be there! 

Our motto #makebetterscience  will continue:

Visit Altertox Academy and sign up for the newsletter here

New EPA Plan to Reduce Animal Testing Will Protect Animals, the Environment, and Taxpayers (The Hill)



It’s worth noting how bipartisan and widely-appealing these efforts have always been, even in otherwise politically divided times. Three-quarters of Americans want to end animal testing. It’s been a pleasure over the years to work with diverse stakeholders ranging from the American Chemical Society, to the Johns Hopkins Bloomberg School of Public Health, to the animal-testing watchdog group White Coat Waste Project.

I applaud the EPA for recognizing that we can protect animals, the environment and taxpayers by sending animal testing to the trash bin of history.

Full Article from The Hill by Rep. Ken Calvert (R-California)

Abstract Submissions and Registration for the 21st Congress of the European Society of Toxicology In Vitro Now Open

June 8-11, 2020
Barcelona, Spain

Details and Registration

11th World Congress on Alternatives and Animal Use in the Life Sciences 2020 (WC11)

Stay updated via the official website and subscribe to the official WC11 newsletter for important news and developments.


Best wishes from all of us,

The CAAT Team


hand holding centrifuge tubes

Upcoming Events

ALTERTOX Academy Training:
Novel In Silico Models for Assessment of Cosmetics
October 17-18, 2019
Milan, Italy

Final OpenRiskNet Workshop: Creating Powerful Workflows Combining Data and Software Services Demonstrated on Risk Assessment Case StudiesWorkshop
October 23-24, 2019

ALTERTOX Academy Training:
Good In Vitro Methods in Practice
November 6-7, 2019
Gothenburg, Sweden

JHU Exposome Collaborative Launch Event
November 8, 2019
Baltimore, Maryland

ALTERTOX Academy Training:
In Vitro Lung Models
November 14-15, 2019
Geneva, Switzerland

ALTERTOX Academy Training:
Acute and Chronic Cardiotoxicity: CiPA (In Silico & In Vitro) Assays
November 14-15, 2019
Leiden, The Netherlands

ACT 2019 Annual Meeting
November 17-20, 2019
Phoenix, Arizona

ALTERTOX Academy Training:
Irritation Oculaire In Vitro
November 21, 2019
Lyon, France

ALTERTOX Academy Training:
Skin Sensitization
November 21-22, 2019
Trier, Germany

60 Years of the 3Rs: Lessons Learned & the Road Ahead
November 22, 2019
Baltimore, MD

Accelerating the Transition Towards Animal-free Innovations
November 27-29, 2019
Utrecht, The Netherlands
Practical Methods for In Vitro Toxicology
January 13-16, 2020
Gaithersburg, MD

ESTIV Applied In Vitro Training Course
April 5-10, 2020

5th International Conference on Alternatives for Developmental Neurotoxicity (DNT) Testing
April 6-8, 2020
Konstanz, Germany

3Rs Symposium: Practical Solutions and Success Stories
June 4-5, 2020
USDA National Agricultural Library
Washington, DC

QSAR 2020: From QSAR to New Approach Methodologies
June 8-10, 2020
Durham, NC

ESTIV 2020
June 8-11, 2020

7th Annual 3Rs Symposium: Practical Solutions and Success Stories
June 4-5, 2020
USDA National Agricultural Library
Beltsville, Maryland
Full Listing of CAAT Programs
and Activities



Copyright © 2019 Johns Hopkins Center for Alternatives to Animal Testing, All rights reserved.

US Office: 615 N. Wolfe St. W7032 • Baltimore, MD 21205
Phone: 410-614-4990 • Fax: 410-614-2871

European Office: University of Konstanz
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Phone: +49-531-882233 • Fax: +49-7531-884156