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Updates from the Center for Alternatives to Animal Testing (CAAT)
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CAATwalk
August 20, 2021

News and Updates from CAAT

   Contents:



ALTEX Report: Hundreds of UK and EU Cosmetics Products Contain Ingredients Tested on Animals

Analysis published in ALTEX finds chemicals tested on animals in many cosmetic products, despite ban

Excerpted from The Guardian:

Hundreds of cosmetic products sold in the UK and Europe contain ingredients that have been tested on animals, despite bans that outlawed such testing years ago, a new analysis has shown.

Banned tests were performed on ingredients used in products including moisturisers, lipsticks, sunscreen and hair conditioner, the analysis found, with more than 100 separate experiments performed on animals including mice and rabbits.

“European customers can’t assume the products they buy are not tested on animals,” said Thomas Hartung, an expert in alternatives to animal testing at Johns Hopkins University and one of the authors of the analysis. Even products labelled as not tested on animals may contain some ingredients that are tested on animals, he said.

Full Article 

Link to Paper:
Knight, J., Rovida, C., Kreiling, R., Zhu, C., Knudsen, M. and Hartung, T. (2021) “Continuing animal tests on cosmetic ingredients for REACH in the EU”ALTEX - Alternatives to animal experimentation. doi: 10.14573/altex.2104221.
 



Alan Goldberg Named Ambassador of Compassion for American Visionary Art Museum's Healing & the Art of Compassion (and the lack thereof!) Show

Alan M. Goldberg, PhD, is Founding Director (Emeritus) of the Center for Alternatives to Animal Testing

From Rebecca Hoffberger, founder of the American Visionary Art Museum:

Years ago I devoted a year to an exhibition entitked, “Home & Beast.” As happens with AVAM’s magic, the focus on our relationship to animals and how we humans share the one home with all that lives (answer: poorly) coincided with the 25th Anniversary of CAAT. Alan Goldberg and I collaborated on a private guided tour which we led together, and he then held the dinner for the many researchers and physicians who had taken up CAAT's mission as their own.

Alan Goldberg has inspired physicians and researchers from all over the world to find and adopt non-animal testing alternatives. His attendees were powerfully moved by an exhibition so in sync with their ideals. Our national museum and education center, right from it’s initial twinkle in my eye, always sought to weave together the works and thoughts of creative visionaries throughout all aspects of human endeavor, not limited to simply visionary artists, but rather inclusive of scientists, engineers, philosophers, human rights activists, farmers—all who creatively aim to better lives.

Therefore, I have been privileged to collaborate with truly outstanding human rights activists like Archbishop Desmond Tutu, Julian Bond, Dame Anita Roddick, and Patch Adams MD; inventors and innovators like Martine Rothblatt, Ray Kurzweil, Dean Kamen, Peter Agre MD, and Abel Wolman—my hero for whom I dedicated our exhibition, “Holy H2O: Fluid Universe,”; and comedians like Matt Groening and Lewis Black who wield humor to speak truth to power.

In our new year-long focus on the twin forces of healing and compassion, the passion wedded to Alan Goldberg’s career is so expressive of intense caring to alleviate animal suffering and at an orchestrated and unprecedented scale. This makes Alan once again an ideal collaborator and worthy show Ambassador. Simply put, Alan Goldberg never fails to inspire me with his depth of sincerity and care for ameliorating life. We are so lucky to be working with him yet again.

We are also asking institutions and clergy to adopt, in their own voice, a focus on Healing and Compassion, to magnify the intention for good of our show. AVAM has never just been about art as object, but rather as mechanism to deepen understanding and inspire better action.

Healing & the Art of Compassion (And the lack thereof!) begins with a private opening on October 8, 2021. The exhibition opens for the public October 9th. 

Full details may be found at:

American Visionary Art Museum
 



Join the Team: Positions Available at CAAT

CAAT is growing its team and we are looking for professionals at any level of experience in the following areas:
  • Communications and Social Media Management
  • Event Planning and Logistics 
  • Metabolomics
  • Computational Toxicology

If you, or someone you know, are interested in learning more about those positions, please email Camila Januario at cjanuar1@jhu.edu

 



CAAT at the 11th World Congress on Alternatives and Animal Use in the Life Sciences


Join via WC11 conference portal or register here.


CAAT Presentations
(All times are CST)

MONDAY AUGUST 23rd DAY 1

KATHRIN HERRMANN (Co-Chair and Speaker)
7.00 - 9.00 PM
S196: Barriers of Refinement Use in Practice (Theme: Ethics, Welfare and Regulation)
Refinement research has the potential to improve the lives of many animals. However, implementation of Refinement is often limited, even when Refinements are based on scientifically sound discoveries. Barriers to implementation may include: economical constraints, apprehensions about changes to data, limitations in products marketed by animal research suppliers and people (their cultural backgrounds, attitudes and beliefs towards animals). This workshop explores what is perceived as the potential barriers to implementation of Refinement, with the aim of highlighting paths forward for successful application. Real case studies will be presented to reveal existing barriers and as examples on ways to achieve change.
 
Abstract ID 366 - Education and training to fully Implement refinement methods in practice - KATHRIN HERRMANN


TUESDAY AUGUST 24th DAY 2

THOMAS HARTUNG
3.00 - 5.00 PM
S114: Artificial Intelligence for Risk and Safety Assessment (Theme: Innovative Technologies)
Artificial Intelligence (AI) consists of an array of methodologies that are capable of extracting complex patterns from big data. The session will discuss the basic concept and methodologies of AI applied in predictive toxicology. The 21st century toxicology has increasingly used new tools, particularly alternative methodologies which generates new data streams. With examples from risk assessment and drug development, the guiding principle and best practice of applying AI in toxicology will be discussed with a specific emphasis on application for the new data streams.

THOMAS HARTUNG
6.30 - 8.30 PM
S205: A Virtual Human Platform for Safety Assessment
The Virtual Human Platform for Safety Assessment (VHP4Safety) is a new integrated approach for assessing safety, based on quantitative information of human biology, toxicology and exposure. The VHP4Safety will form an overarching platform integrating high quality data from existing data(bases) and algorithms, as well as new data acquired within the project. During this session we dive into the topic of predictive modelling, data science, exposure assessment and advanced human in vitro models, to design a platform that reflects the Virtual Human and address the emerging societal challenge towards transition to animal-free safety assessment completely based on human data.

WEDNESDAY AUGUST 25th DAY 3

MARCEL LEIST
3.00 - 5.00 PM
S70: Challenges of Non-Animal Approaches for Food Safety & Nutrition in the 21st Century: From Inception to Application (Theme: Safety)
This session proposal aims to discuss:
  • Different applicable legislations for non-animal approaches in the food sector
  • The way food scientists approach animal and animal-free studies
  • Benchmarking of non-animal approaches in different industry sectors
  • Real life risk assessment application in food safety and nutrition
ALEX MAERTENS
6.30 - 8.30 PM
S105: The role of clinical research on the understanding and treatment of diseases (Theme: Disease)
Clinical-based research can, for example: explore specific genes, gene sequences or patterns that may be involved in the aetiology of a disease; perform neurological examinations to identify areas involved in specific diseases; describe the biochemical and physiological changes that occur during the development of a disease; or understand relevant psychological and epidemiological factors that can play a role in the development of a disease.

Better collection, sharing, and utilisation of human-based knowledge can improve the integration of multidisciplinary approaches, understanding of the pathophysiology of specific diseases and development and testing of new therapies, whilst limiting the use of other animals.
 

THURSDAY AUGUST 26th DAY 4

LENA SMIRNOVA
3.00 - 5.00 PM
S177: Innovative approaches for CNS research - from brain organoids to new single cell culture methods (Theme: Innovative technologies)
A functioning central nervous system (CNS) is key for living, and ageing is a major risk factor of disfunction. With the increase in human lifespan the incidence of neurodegenerative diseases is rising. There is a demand for good models for neurodegenerative diseases, as current in vivo models have limitations and ethical concerns.

Modeling the CNS in vitro is, however, challenging. Recent discoveries in neuroscience, such as the breakthroughs of induced pluripotent stem cell technology, 3D-organotypic cultures and organs-on-chip, move the field forward. This workshop will overview how scientists are embracing new cutting-edge technologies and provide a guidemap for future developments.

FRANCOIS BUSQUET, ALTERTOX ACADEMY 
3.00 - 5.00 PM
S195: Industry and public sector partnerships in education to foster the implementation of alternative methods (Theme: Ethics, Welfare and Regulation)
Abstract ID 496 - Ways to improve their effectiveness and recognition 

Newer alternative methods to animal tests in toxicology are increasingly using advanced techniques. These are sometimes more complex than historical animal tests and their appropriation by stakeholders, CROs, safety evaluators, regulatory bodies require new knowledge, equipment and also availability of the test systems. Their validation is a must but not always sufficient to be accepted everywhere. To be trusted and routinely used there is a need of communication and training at an international level for both current professionals and next generation of toxicologists. 

In this context a number of initiatives involving private companies in partnership with educational/research institutions, learned societies and nonprofit organizations have emerged to organize theoretical as well as hands-on-training of human-relevant alternative methods. This allows students, scientists and toxicologists, to quickly become familiar with newer methods and to better understand how to use the results for GHS (global harmonization system) classification or risk assessment. In these approaches the notion of partnership is crucial. On one hand, private companies, such as methods providers or end-users, have expertise and access to technologies and methods. On the other hand, public establishments, academic institutions or learned society are representative of the intended population and have legitimacy in education.

After a short presentation of some examples involving private and public/nonprofit players conducted in Europe, South America, India or China this round table will discuss some of the barriers experienced (funding, mistrust...), definition of education and training good practices (mixing theory and practice, hosting laboratory...) and ways to improve the effectiveness and recognition of these courses (university partnership, certification, webinars...). Finally, the interest of coordination and generalization of this kind of partnerships to accelerate the spread of alternative methods to animal experimentation worldwide will be discussed.

MARCEL LEIST & GIORGIA PALLOCCA (Session Chair and Co-Chair)
Speakers: THOMAS HARTUNG, MARTIN STEPHENS, COSTANZA ROVIDA, FRANCOIS BUSQUET

6.30 - 8.30 PM
S85: A walk through 10 years of CAAT-Europe’s highlights
The Center for Alternative to Animal Testing in Europe (CAAT-Europe), housed at the University of Konstanz, coordinates transatlantic activities to promote the development of new and improved methods in toxicology, to provide a platform for different stakeholders for exchanging ideas, and to support the 3R’s principle of human science. CAAT-Europe is going to celebrate the 10th anniversary of its foundation, with a session focused on the most relevant CAAT articles that have been published in the last years. The presentations will cover several topics, as in vitro regulatory, systemic and investigative toxicology, including the application of omics, microphysiological systems and good practice guidance for supporting a human-centered toxicity testing paradigm change. Each speaker will introduce a single publication to tell the story behind its compilation and to discuss its implication and impact on the actual and future discussion in the 3Rs field.
 

FRIDAY AUGUST 27th DAY 5

THOMAS HARTUNG
2.30 - 3.00 PM
WC11 TV - Live from the studio. 

FRANCOIS BUSQUET
3.00 - 5.00 PM
Data Access and EU Institutions

MONDAY AUGUST 30th DAY 6

MARTIN STEPHENS AND KATHRIN HERRMANN (Session Chairs)
Speaker: HELENA HOGBERG
6.30 - 8.30 PM
S84: Beyond the 3Rs: Expanding the Use of Human-Relevant Replacement Methods in Biomedical Research (Theme: Disease)
The current landscape of alternative methods calls for a strategic focus on (1) biomedical research (where many human disease processes remain unclear), (2) replacement methods (given the myriad types of models now available (e.g., organs-on-a-chip), and (3) human relevance (given problems with the current translatability of models). This roundtable will reflect this strategic focus by addressing the use of human relevant models in several areas of biomedical research, including cardiovascular disease, Alzheimer disease, autism, and cancer.
 

TUESDAY AUGUST 31st DAY 7

THOMAS HARTUNG
1.00 - 1.30 PM
WC11 TV - Live from the studio.  

WEDNESDAY SEPTEMBER 1st DAY 8

FRANCOIS BUSQUET (Session Chair and Speaker)
6.30 - 8.30 PM
Smart use of social media in 3Rs
skills4science
Young researchers dedicate rightfully most of their time to core knowledge production via laboratory experiments, reading peer-review literature, publishing own results, attending conferences whenever possible as well as undertaking trainings on writing grants, papers among many other activities However, the promoter argue here that restricting them to this unique set of activities is jeopardizing creativity and reducing awareness of a more complex picture in science. Other fields linked with social sciences, including scientometrics and epistemological areas covered during conferences and continuous education, may contribute to a more productive working environment for young researchers. This session would be the opportunity to kick-off the discussion and tackle some of these "secondary" topics. This was first covered in the following article "The use of social media in scientific research and creative thinking" by Busquet & Vinken https://doi.org/10.1016/j.tiv.2019.04.006

THURSDAY SEPTEMBER 2nd DAY 9

SPEAKERS: THOMAS HARTUNG & KATHRIN HERRMANN
Session chair and co-chair: MARTIN STEPHENS AND KATHRIN HERRMANN
3.00 - 5.00 PM
S216: Animal Experimentation: Working Towards a Paradigm Change (Theme: Ethics, Welfare and Regulation)
New human biology-based tools should facilitate a strong shift away from animal experimentation. However, in research, animals are still widely seen as the default option, even though interspecies differences compromise translation to the humans. In this workshop we discuss some of the obstacles and driving forces of change. We address the vague public policy provisions regarding animal replacement; the limited education and training possibilities on human-relevant approaches; insufficient funding for the development of non-animal models; psychological lock-in and entrenchment in science; and public misinformation about animal experimentation, as well as how education, funding redeployment, and political action can drive change.

Abstract ID 832 - Educating Future Scientists and Raising Public Awareness on Animal-free Experimentation 
K. Herrmann

Abstract ID - Research and Testing Without Animals: Where Are We Now and Where Are We Heading? 
T. Hartung

Full Program (WC11 Website)
 



SAVE THE DATE!
CAAT 40th Anniversary Symposium

September 21, 2021
10am - 1pm EST (US and Canada)
Online

Please save the date for the celebration of CAAT's 40th birthday on September 21, 2021. The program will features special guests and friends of CAAT from its 40 year history promoting and shaping the field of alternatives and humane science. You won't want to miss this special event!

Register in advance for this meeting here.

After registering, you will receive a confirmation email containing information about joining the meeting.

Watch for updates in upcoming CAATwalks!

 



Next Generation Humane Science Award: Application Period Now Open

Completed Applications Due by 11:59pm on September 12, 2021

The Next Generation Humane Science Award is available annually to young scientists to acknowledge and encourage researchers who focus on replacing the use of animals in experiments. The 2021 award will be a prize of up to $5,000 to recognize the work of one young scientist; this may be shared among two or more young scientists. Please email completed application to caat@jhu.edu.

Qualification Criteria

The work must be focused on the replacement of animals used in experimentation. Excellence of research outcome as demonstrated by publications and presentations at scientific meetings. The review committee will also take into account:

  • The significance of the potential to replace animal experiments in the future.
  • Providing an inspiration to others (fellow students, members of the research group) and outreach to wider audiences.
  • The potential for the replacement methodologies to be used in a regulatory context.

2021 Eligibility Criteria

  • The candidate must be a citizen or permanent resident of the United States working at a US-based institution.
  • The candidate should not have received a PhD or similar degree earlier than 2012.
  • Current and former employees (or their family members) of the Center of Alternatives to Animal Testing at Johns Hopkins University cannot apply.
Full Details and Application
 


Challenges and Opportunities for Overcoming Dog Use in Agro-chemical Evaluation and Registration

October 25th, 2021
9am-1pm EDT
Online

The 90-day dog study is being conducted for agro-chemical authorization when it is not always needed to adequately address hazard identification and human safety and risk. This virtual workshop will host a series of presentations on the role the dog study has played in regulation of agro-chemicals in both the U.S. and Europe during the past 20 years and what approaches may be employed to substantially reduce its use. The public will have the opportunity to submit comments and questions to be discussed during the following invitation-only workshop.

Details and Registration
 


SAVE THE DATE!
EBTC 10th Anniversary Symposium

November 11, 2021
Online

Please save the date for the Evidence-Based Toxicology Collaboration's 10th anniversary symposium, which will be held online on November 11, 2021. 

Further details will be forthcoming in this newsletter and on the EBTC website

 



Microphysiological Systems World Summit

SAVE THE DATES!

Virtual Conference: Systems Engineering of Microphysiological Systems

December 9, 2021

Hybrid Conference
May 30-June 3, 2022
Hilton New Orleans Riverside

The MPS World Summit will bring together a global audience—including institutions (government, health foundations, charities), the academic research community (universities, research institutes), environmental and human toxicity researchers, the pharmaceutical and other industries (cosmetics, chemical, and food industries), medical centers and practitioners, patient associations, and policy makers and testing centers—in a series of global conferences to create A roadmap for MPS technologies.

Gold sponsor
Emulate

Bronze sponsor
Nortisbio
 
Silver sponsors
Hesperos
AxoSim
InSphero

Exhibitor
Aracari
Mimetas

BECOME A SPONSOR!

Multiple sponsorship levels are available. Please see our sponsorship flyer (PDF) and visit this link to request sponsorship information.

Visit the MPS World Summit website for full information.

 


Best wishes from all of us,

The CAAT Team

     

hand holding centrifuge tubes

Upcoming Events


11th World Congress on Alternatives and Animal Use in the Life Sciences
August 23-September 2, 2021
Maastricht, The Netherlands

Online Symposium: Alternatives to Matrigel
September 10, 2021
Online

CAAT 40th Anniversary Symposium
September 21, 2021
Online

EUROTOX 2021
September 26-October 1
Online

ASCCT Annual Meeting
October 12-14
Online

Advances in Cell and Tissue Culture 2021 Virtual Conference
Part 2: November 3, 2021
Online

EU-ToxRisk Final Symposium
November 3-4, 2021
Brussels, Belgium

EBTC 10th Anniversary Symposium
November 11, 2021
Online

Lung In Vitro Model Training
November 18-19, 2021
Geneva, Switzerland

Altertox: Skin Sensitization
25-26 November 2021
Hamburg, Germany

MPS World Summit Virtual Conference
Systems Engineering of Microphysiological Systems
December 9, 2021
Online

Microphysiological Systems World Summit
May 30-June 3, 2022
New Orleans

LIVe2022
June 13-14, 2022
Nice, France 

ICT 2022
September 18-22, 2022
Maastricht, The Netherlands

21st International Congress of the European Society of Toxicology In Vitro (ESTIV2020)
November 21-25, 2022
Barcelona

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