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Updates from the Center for Alternatives to Animal Testing (CAAT)
CAATwalk
October 14, 2021

News and Updates from CAAT


Berlin’s Animal Protection Commissioner Awards for Animal-free NAMs Development for Biomedical Research

Kathrin Herrmann, CAAT’s Beyond Classical Refinement Program Director, who is also Berlin’s Animal Protection Commissioner, is pleased to announce two Awards for the development of NAMs to actively support the shift from tradition-based animal experimentation to human-relevant health research: The Early Career Scientist Award is for a promising research proposal from an up-and-coming scientist that will advance the development and uptake of NAMs; the second Award is for an already ongoing, auspicious project developing and/or using NAMs that needs additional funding for continuation. Each Award includes prize money of 30,000 €.
Deadline: October 17 2021
More Information and Guidelines to apply: https://www.berlin.de/lb/tierschutz/preisauslobung/artikel.1121707.php

Please join us Thursday, October 21st for the next in the joint ASCCT/ESTIV webinar series: EU REACH Regulation, EU Cosmetic Regulation, and new animal tests on cosmetic ingredients, featuring Costanza Rovida, CAAT-Europe/Konstanz University and Jean Knight, White Rabbit Beauty. 
Registration is now open


EU REACH Regulation, EU Cosmetic Regulation, and new animal tests on cosmetic ingredients
EU Regulations are legislative acts that are immediately implemented in all 27 member states of the European Union. REACH is the most important regulation in the chemical area, requiring all manufacturers and importers of chemicals in quantities above 1 ton/year to register the substances. The registration includes a detailed risk assessment, often based on new animal testing. Cosmetic ingredients are chemical substances that need full REACH registration. In addition to that, cosmetic ingredients are governed by the EU’s Cosmetic Regulation, which is focused on the protection of consumers when using cosmetics. Since 2009 for some endpoints and 2013 as a general rule, the Cosmetic Regulation has banned new in vivo tests of both finished cosmetics and cosmetic ingredients. This important ban has caused consumers to believe that EU cosmetics are not tested on animals. In a recent study, we demonstrated that this is not fully true, as many cosmetic ingredients are being tested in vivo for REACH purposes (https://doi.org/10.14573/altex.2104221).

During the presentation we will describe both regulations and we will guide participants through the database of the European Chemical Agency (ECHA) where all the studies performed for registering chemical substances are stored. We will also explain the conflict between the two regulations regarding the possibility to test cosmetic ingredients on animals, by presenting the results of our analysis. Among the in new in vivo tests performed on cosmetic ingredients, some were necessary for REACH compliance, but others should have been avoided. The future is not bright with many more new tests asked by the authority to the registrants.
 

CALL FOR ABSTRACTS!

DEADLINE OCTOBER 21, 2021 (11:59 pm EST)

In preparation of the first MPS World Summit, we are meeting on-line on December 9th to discuss the advances in MPS technology. 
Registration is open! Click here to register.

 

Theme: Systems engineering of Microphysiological Systems
Abstracts are invited on the topic of new developments in MPS: new cellular models (from bio-printing to organoids, etc.) and new approaches in bioengineering of MPS devices.
Describe your newest developments: breakthroughs, advantages, challenges and the field of applications. The top abstracts will be selected for oral presentations in one of two sessions: (1) MPS hardware and enabling technologies; (2) Cell models and applications for MPS.

All accepted abstracts will be invited for an electronic poster. There is no submission fee and no conference registration fee. 
Abstract submission guidelines:
• Abstracts must be in English.
• All abstracts will be evaluated and selected by the MPS Scientific Advisory Committee (SAC).
• Please limit abstracts to 300 words.
• References must be cited in the text as (First author et al., Year).
• Pictures, figures, attachments are not permitted - text only.
• Please submit abstract as Word document.
• Include no more than five references.
• All abstracts accepted will be published in an abstract/poster book (PDF) and distributed digitally to all registered attendees.
• Young scientists (35 or under) can apply for consideration for the Travel Award (free registration at the upcoming hybrid meeting in New Orleans), to be held May 30 - June 3, 2022. Please note in the e-mail if you wish to be considered for the Travel Award for young scientists
E-mail abstracts to: info@mpsworldsummit.com

Please note “Abstract” in the subject field. 
Applicants will be informed of acceptance/non-acceptance by November 25, 2021
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Taken from M. Turner (2012) Call to curb lab tests on dogs. Nature 474, 551 reporting on CAAT’s 2012 workshop.

WEBINAR:
Challenges and Opportunities for Overcoming Dog Use in Agro-chemical Evaluation and Registration

October 25th
10 am – 1 pm EST
REGISTER HERE!

The 90-day dog study is being conducted for agro-chemical authorization when it is not always needed to adequately address hazard identification and human safety and risk. This virtual workshop will host a series of presentations on the role the dog study has played in regulation of agro-chemicals in both the U.S. and Europe during the past 20 years and what approaches may be employed to substantially reduce its use. The public will have the opportunity to submit comments and questions to be discussed during the following invitation-only workshop.
Presentations:
• Title: The value of the 90-day dog study in pesticide registration toxicity testing in the U.S.
Authors: Patricia L. Bishop (The Humane Society of the United States), Douglas C. Wolf (Syngenta Crop Protection), and Vicki Dellarco (Independent Consultant)
• Title: Incorporating toxicokinetic and toxicity data to evaluate the value added from using dogs in subchronic toxicity testing for agrochemicals
Authors: Lynea Murphy (Corteva AgriScience), Robert Mingoia (Corteva AgriScience), Jean Domoradzki (Corteva AgriScience) Claire Terry (Corteva AgriScience)
 • Title: Relevance of dog studies for the derivation of health-based guidance values for Plant Protection Products Approval - EFSA
Authors:  Martina Panzarea (EFSA) and Andrea Terron (EFSA)
• Title: Species Liver-Chip to assess cross-species drug toxicity and human relevance.
Author: Kyung-Jin Jang (Emulate)

Organizing Committee
Remi Bars BAYER
Patricia Bishop  HSUS
Kathleen  Conlee  HSUS
Suzie  Fitzpatrick  FDA
Thomas Hartung  JHU
Barry Hooberman FDA
Anna Lowit EPA
Lynea  Murphy CORTEVA
Martina Panzarea EFSA
Martin Stephens JHU
Cecilia Tan EPA
Andrea Terron   EFSA
Claire Terry  CORTEVA
Bennard van Ravenzwaay BASF
Doug Wolf    SYNGENTA
 

Next Generation Humane Science Award:
Extended deadline! Completed Applications
Due by 11:59pm EST on October 24, 2021.

The Next Generation Humane Science Award is available annually to young scientists to acknowledge and encourage researchers who focus on replacing the use of animals in experiments. The 2021 award will be a prize of up to $5,000 to recognize the work of one young scientist; this may be shared among two or more young scientists. Please email completed application to caat@jhu.edu.

Qualification Criteria
The work must be focused on the replacement of animals used in experimentation. Excellence of research outcome as demonstrated by publications and presentations at scientific meetings. The review committee will also take into account:

  • The significance of the potential to replace animal experiments in the future.
  • Providing an inspiration to others (fellow students, members of the research group) and outreach to wider audiences.
  • The potential for the replacement methodologies to be used in a regulatory context.

2021 Eligibility Criteria

  • The candidate must be a citizen or permanent resident of the United States working at a US-based institution.
  • The candidate should not have received a PhD or similar degree earlier than 2012.
  • Current and former employees (or their family members) of the Center of Alternatives to Animal Testing at Johns Hopkins University cannot apply.
Full Details and Application

Non-Animal New Approach Methodologies (NAMs) in Biomedical Research

November 22-23, 2021, 9am-12pm EST/ 3-6pm CET
Online Workshop 
The Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) and the Animal Protection Commissioner of Berlin are inviting early career scientists for a two-day Online Workshop focusing on animal-free New Approach Methodologies (NAMs) in biomedical research. The program will include presentations and interactive sessions. Following the call for abstracts, up to ten early career scientists will be selected to present their own research involving NAMs. The program will also include a session with established scientists from academia, industry, government, and NGOs who will answer the participants’ questions and share advice and guidance on future careers in the field of non-animal methods. In another session, we will discuss topics such as how to tackle the ‘publish or perish’ trap, and where to find funding as well as ongoing training opportunities in NAMs.
The Workshop is free of charge. Please use the form below to apply as well as to submit your abstract (if you would like to present your research) and email it to Dr. Kathrin Herrmann at kherrma1@jhu.eduDeadline is November 7th, 2021. The form to apply can be found here: https://www.berlin.de/lb/tierschutz/alternativen-zu-tierversuchen/artikel.1129019.php


CAAT is a proud partner of the $20 million EU project ONTOX. The vision of the ONTOX consortium is to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next generation risk assessment.


Check out the very first ONTOX newsletter (NL): https://ontox-project.eu/newsletter/ontox-newsletter-1/
 
Subscription for this NL can be found here: https://ontox-project.eu/


Best Wishes,

The CAAT Team

     

hand holding centrifuge tubes

Upcoming Events


EU REACH Regulation, EU Cosmetic Regulation,
and new animal tests on cosmetic ingredients

Thursday, October 21, 2021
Online

Challenges and Opportunities for Overcoming Dog Use in Agro-chemical Evaluation and Registration
October 25th
Online

Advances in Cell and Tissue Culture 2021 Virtual Conference
Part 2: November 3, 2021
Online

EU-ToxRisk Final Symposium
November 3-4, 2021
Brussels, Belgium

EBTC 10th Anniversary Symposium
November 11, 2021
Online

Non-Animal New Approach Methodologies (NAMs) in Biomedical Research
November 22-23, 2021, 9am-12pm EST/ 3-6pm CET
Online

Altertox: Skin Sensitization
25-26 November 2021
Hamburg, Germany

MPS World Summit Virtual Conference
Systems Engineering of Microphysiological Systems
December 9, 2021
Online

Microphysiological Systems World Summit
May 30-June 3, 2022
New Orleans

LIVe2022
June 13-14, 2022
Nice, France 

ICT 2022
September 18-22, 2022
Maastricht, The Netherlands

21st International Congress of the European Society of Toxicology In Vitro (ESTIV2020)
November 21-25, 2022
Barcelona

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