Updates from the Center for Alternatives to Animal Testing (CAAT)
November 8, 2021

News and Updates from CAAT

Alternative approaches in Developmental Neurotoxicity - a farewell symposium for CAAT’s deputy director Helena Hogberg

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals, drugs and consumer products. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests.
This symposium has the objective to discuss and present the status of DNT and honor Helena Hogberg for her 12 years working at the Center for Alternatives to Animal Testing and moving further to NICEATM at NIEHS.
November 30, 2021
10 am - 1 pm EST

10 am Helena Hogberg – Open remarks
10:15 Alan Goldberg and Pamela Lein – DNT—How it all began
10:30  Lena Smirnova – DNT journey of CAAT research
10:45 Ellen Fritsche – Scientific validation of the neurosphere DNT test methods
11:00 Iris Mangas - The DNT programme in EFSA, past, present and future.
11:15 Tim Shafer - DNT NAMs are already being used
11:30 Magda Sachana - OECD DNT project: seeing the light at the end of the tunnel
11:45 Marcel Leist - DNT Europe
12:00 Anna Price – Future of DNT testing: evaluation of effects induced by mixtures using NAMs
12:15 Mamta Behl - Beyond DNT-  A great colleague and a wonderful friend
12:30 Thomas Hartung – Director remarks
12:45 Helena Hogberg – Closing remarks

Register here.

EBTC 10th Anniversary Symposium

November 11, 2021
10 am – 12 pm EST

10:00 Introduction 5 min (Marty Stephens, Founding Director of EBTC)
10:05 Keynote: History of EBT movement and application in diverse fields (Thomas Hartung, Professor of Evidence-based Toxicology, Johns Hopkins Bloomberg School of Public Health)

Presentations on use cases of Evidence-based Toxicology 
10:20 History of implementation of SR methods at IRIS (Kris Thayer, US )
10:35 Certainty in evidence for environmental health claims (Holger Schunemann)
10:50 Systematic Review at EFSA (Didier Verloo, EFSA)
11:05 Harnessing Artificial Intelligence to Bridge the Systematic Method and Environmental Health Data Divide
(Michelle Angrish, US EPA)
11:25 Panel with users of evidence: Moderated by Jack Fowle, President of EBTC Board of Trustees.

Kris Thayer, Director of US EPA IRIS and EBTC Board Member
Bette Meek, University of Ottawa
Tala Henry, US EPA
Richard Brown, WHO
Bennard van Ravenzwaay, BASF

11:45 Looking at the next decade for Evidence-based Toxicology : Katya Tsaioun 

Register here.


International Foundation for Ethical Research (IFER) Presents Fellowships to CAAT's Graduate Students Ishita Virmani and Alan Kim

Each year the International Foundation for Ethical Reserach (IFER) presents Graduate Fellowships to those Master's and Doctoral students whose proposals show the greatest potential to contribute towards the reduction, refinement, and replacement (3R's) of animal-use in research, testing and/or education. Ishita Virmani and Alan Kim are the proud members of the CAAT family whose proposals were selected and we expect them to continue into a very productive year!

Thomas Hartung to speak at the BfR-symposium on "New Methods, Omics and Novel Concepts in Toxicology – Current Application and future Directions"

November 15–17, 2021, physically in Berlin and in parallel online.

The symposium will highlight methodological progress (e.g. in vitro, in silico, omics methods) as well as current and future applications for regulatory risk assessment.
Final program as well as to the  open registration form

2-day Early Career Scientists Online Workshop on NAMs in Biomedical Research 
November 22-23, 2021, 9am-12pm EST/ 3-6pm CET Online Workshop 
Deadline Extension until November 15, 2021, 11.59 pm EST

More information here
CAAT and the Animal Protection Commissioner of Berlin are inviting early career scientists for a two-day Online Workshop focusing on animal-free New Approach Methodologies (NAMs) in biomedical research. The program will include presentations and interactive sessions. Following the call for abstracts, up to ten early career scientists will be selected to present their own research involving NAMs. The program will also include a session with established scientists from academia, industry, government, and NGOs who will answer the participants’ questions and share advice and guidance on future careers in the field of non-animal methods. In another session, we will discuss topics such as how to tackle the ‘publish or perish’ trap, and where to find funding as well as ongoing training opportunities in NAMs.

The Workshop is free of charge. Please use the form on the website to apply and to submit your abstract (if you would like to present your research) via email to Dr. Kathrin Herrmann at Deadline is November 7th, 2021.


The Role of Public Awareness in the Replacement of Animals In Safety Testing

November 24-25, 2021 (1:00 pm - 4:00 pm UK time)

Dr Kathrin Herrmann, (CAAT and Animal Protection Commissioner of Berlin, Germany and Dr Costanza Rovida, CAAT-Europe, will be presenting at the LUSH PRIZE CONFERENCE 2021
More information and free registration here


Copyright of Photo: Anne van Veen

The principles of the 3Rs: Lessons Learned from History.
Talk by Anne van Veen, PhD, Radboud University, Nijmegen, The Netherlands

December 7, at 7 pm CET

The 7th Webinar in the 3Rs training series, organized by the Animal Protection Commissioner of Berlin and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), in collaboration with the Veterinary Chamber of Berlin, will take place on Tuesday, December 7, at 7 pm CET. Dr. Anne van Veen, PhD, Radboud University, Nijmegen, The Netherlands, will give a talk about lessons learned from the uptake of the 3Rs so far. She will discuss barriers to a transition towards animal-free innovation as well as opportunities generated by societal involvement and citizen-science collaboration to help move the transition along. After her talk, there will be time for questions and a discussion.
More information and free registration via Eventbrite

Join us for our second MPS World Summit Virtual Pre-Conference

Systems engineering of Microphysiological Systems
December 9th 2021, 9 am – 1 pm EST

In preparation of the first MPS World Summit, we are meeting on-line on December 9th to discuss the advances in MPS technology. 

9:00  Welcome, Thomas Hartung, JHU
9:05  Keynote Address: Donald Ingber, Wyss Institute, Harvard University
9:35  "MPS Hardware and Enabling Technologies" (short talks from submitted abstracts)
10:55 Break and poster voting
11:00 "Cell Models and Applications for MPS" (short talks from submitted abstracts)
12:20  Panel discussion and Q&A

Panel participants:
Adrian Roth, Roche - moderator
Linda Griffith, Massachusetts Institute of Technology
Alysson Moutri, University of California San Diego
Peter Loskill, Tuebingen University
Uwe Marx, TissUse
Hiroshi Kimura, Tokai University

12:50 Young Investigator Travel Award announcement and closing remarks

Registration is open! Click here to register.

Our CAAT workshop:
Bouhifd, M., Beger, R., Flynn, T. et al. (2015). Quality assurance of metabolomics. ALTEX 32, 319-326. doi:10.14573/altex.1509161 stimulated the creation of the Metabolomics QA & QC Consortium (mQACC). Please join their next webinar.

The Quality of Metabolite Annotation & Identification in LC-MS-based Untargeted Metabolomics
Tuesday, November 30th at 11:00 am EST | 5.00 pm CET
Join us virtually for the next session in the “mQACC Best Practices in QA/QC” Interactive Forum series. Lend your voice and help inform best practices regarding the quality of metabolite annotation and identification in LC-MS-based untargeted metabolomics!
The interactive forum series is designed to facilitate priority setting by participants via live polling, followed by a guided discussion. During the next session we will focus on the quality of metabolite annotation and identification for untargeted LC-MS metabolomics. As defined by the Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)1, metabolite identification is the assignment of two or more independent and orthogonal data relative to an authentic standard analyzed under identical experimental conditions (MSI Level I). Conversely, metabolite annotation is the tentative assignment of data based on physicochemical properties and/or spectral similarity to known compounds (MSI Level II) and compound classes (MSI Level III). The lines of evidence and computational resources used both for metabolite annotation and identification during untargeted metabolomics can vary vastly from study to study and from lab to lab. Thus, the broader metabolomics community feedback is needed for understanding the range of practices used by labs, both to educate newcomers on the importance of confident compound identification during metabolomics analysis and to forge a direction toward standardization of this key QA/QC step.
Registration is done on a first-come, first-serve basis, and attendance will be capped at 100 participants. The registration will remain open until Sunday, November 28th, 2021. Please direct any questions to


Deadline: January 15, 2022

Application criteria

The applicants must fulfill the following criteria:

  • The application should focus on the innovative development and / or application of animal-free antibodies for research or medical purposes
  • The application can be for ongoing or completed projects
  • The project must not contain any animal experiments or animal-derived products such as fetal calf serum (FCS), bovine serum albumin (BSA), milk powder, etc.
  • The applicants must be based on the continent of Europe. Applicants from EU and non-EU member states in Europe are welcome to apply
  • The applicants must be prepared to accept the prize at an event in Brussels in spring of 2022, and give a short presentation. Travel expenses will be covered

Prize amount and award ceremony

The prize amounts to €10.000 and can be awarded to an individual researcher or a researcher consortium, a university department, an industrial company or other type of research facility. The prize will be awarded at an event in Brussels in March/April 2022.

Application documents

Please submit the following application documents in English:

  1. A project description containing title, abstract, short background, research aims, methodological procedures, time plan and project milestones (for ongoing projects) or outcomes of the project (for completed projects). The project description should be focused on the development or application of animal-free antibodies and it should include a declaration that no animal experiments were performed and no animal-derived materials were used, including in buffers, cell media, blotting reagents, etc. (up to 6 pages).
  2. A description of the applicant’s motivation to develop and / or use animal-free antibodies (1 page).
  3. A tabular curriculum vitae of the applicant with a publication list.
Call for tender as PDF 

Contact person: Dr. Dilyana Filipova E-mail:


1. EU Science Hub - European Commission: Better antibodies without using animals. 11.5.2020

2. Viegas Barroso JF et al. EURL ECVAM recommendation on non-animal-derived antibodies, Publications Office of the European Union, 2020

Calling all students and early-career researchers interested in innovative approaches in toxicology and biomedical sciences


IUTOX XVIth ICT 2022 – Online registration and abstract submission open
IUTOX XVIth International Congress of Toxicology (ICT) 2022 is now available on the website  The IUTOX XVIth ICT 2022 will take place in Maastricht, Netherlands from September 18 to 21, 2022.
Under the congress theme “Uniting in Toxicology”, ICT 2022 aims to set up a diverse congress program that makes the various disciplines the subject of joint discussions.
Working together, these disciplines with their diverse perspectives contribute to promoting and encouraging the use of new and innovative techniques and strategies, that will continue to reduce the risks to human health and the environment.
Seven Continuing Education Courses (CECs), 28 top-notch scientific sessions as well as keynote lectures from renowned scientists and platforms for young scientists will cover these aspects with more than 1,500 participants and more than 60 exhibitors on four eventful days in MECC Maastricht, located in one of the most European cities. The scientific program can be found here.
The IUTOX XVIth ICT 2022 Organizing Committees cordially invite you to join us on this occasion and warmly welcome all novel contributions for poster and short oral communications.
Do not miss out on one of the largest and most significant toxicology congresses and register online now!
Deadline for Abstract Submission: March 31, 2022          
Deadline for Registration at the Early Bird Fee: May 15, 2022

Please note: For abstract submission, online registration for the congress is required first.
In case of any questions or concerns, please do not hesitate to contact us at Updated information about the congress is always available online:

Best Wishes,

The CAAT Team


hand holding centrifuge tubes

Upcoming Events

EBTC 10th Anniversary Symposium
November 11, 2021

2-day Early Career Scientists Online Workshop on NAMs in Biomedical Research 
November 22-23, 2021
9 am-12 pm EST


Alternative approaches in Developmental Neurotoxicity - a farewell symposium for CAAT’s deputy director Helena Hogberg
November 30, 2021
10 am - 1 pm EST

The principles of the 3Rs: Lessons Learned from History.
Talk by Anne van Veen, PhD, Radboud University

December 7, 2021
7 pm CET

MPS World Summit Virtual Conference
Systems Engineering of Microphysiological Systems
December 9, 2021

Altertox: Skin Sensitization
March 10-11, 2022
Hamburg, Germany

Altertox: Novel In vitro Methods and AOP Approaches in Genetic Toxicology
May 19-20, 2022
Oegstgeest, The Netherlands

Microphysiological Systems World Summit
May 30-June 3, 2022
New Orleans

June 13-14, 2022
Nice, France 

ICT 2022
September 18-22, 2022
Maastricht, The Netherlands

Altertox: In vitro Lung Models
November 3-4, 2022
Geneva, Switzerland

21st International Congress of the European Society of Toxicology In Vitro (ESTIV2020)
November 21-25, 2022

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