Starting in July, Chrome will begin warning people if a website is not secure. This could cause people to not visit or leave your site if they are considered about security. Read more about that on Google's blog and make this a priority if it does not already apply to your site.
Google Chrome Ad-Blocker
You may have seen some chatter about Google Chrome's Ad Blocker. If you run AdWords campaigns and are concerned about the impact, the short version is that you'll be fine. No need to worry about it.