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The Journey Newsletter (March 2022)
The OHDSI community came together for "Phenotype Phebruary" to both develop and evaluate phenotypes for health outcomes that could be investigated by the community. We reflect on that effort, the recent European Medicines Agency announcement of the DARWIN EU Coordination Center — and how OHDSI fits in that initiative — and discuss plenty more that happened in the community in the latest edition of The Journey! #JoinTheJourney
March Update Videocast
Patrick Ryan and Craig Sachson discuss why "Phenotype Phebruary" was such a positive community activity, and how it can help OHDSI research initiatives in the future. They also discuss the recent EMA decision to award OHDSI collaborator Erasmus MC with the DARWIN EU contract, and they reflect on the recent Workgroup Leadership Summit.
Community Updates
Where Have We Been
• The community engaged in the Phenotype Phebruary initiative, with 15 different collaborators leading 28 conversations about phenotypes. While the calendar has turned, the value in continuing these conversations remains. You can find all threads on developing and evaluating these phenotypes later in the newsletter.
• Leads from most OHDSI workgroups convened for a leadership summit in early February to highlight 2022 Objectives and Key Results (OKRs), and also discuss best practices for leading their respective teams. To learn more and see the 2022 OKRs, please visit our new workgroups page.

Where Are We Now
• The OHDSI community will work with the Erasmus Medical Center to set up the coordinating center for the new DARWIN EU initiative, which was developed by the European Medicines Agency. Read more about this initiative in the newsletter.
Clair Blacketer will lead a two-part CDM 5.4 workshop during our March 8 and 15 community calls. Check out the full March schedule later in this newsletter.

Where Are We Going
The 2022 OHDSI Symposium will be held Oct. 14-16, with the main symposium set for Friday, Oct. 14. More details should be available shortly, but please save those dates. 
• The new Open-Source Community Workgroup will host a Developer Conference (DevCon) on Friday, April 22, with plans for several workshops and discussions around new projects and new methods. More information, including how to submit abstracts, will be shared on community calls and our social platforms in March.

How Can You Join
The OHDSI research community strives to promote better health decisions and care through globally standardized health data, continuously developing large-scale analytics and a spirit of collaboration though open science. We are proud to have more than 2,700 collaborators across six continents, as well as health records for about 810 million unique patients from around the world.

We are always looking for new collaborators, so if this sounds exciting to you, please read about how you can Join The Journey!
“Phenotype Phebruary” was a community-wide initiative to both develop and evaluate phenotypes for health outcomes that could be investigated by the community. We were so proud to have 15 different members of the community step up and lead forum discussions on phenotypes ranging from Type 2 Diabetes Mellitus and Hypertension to Depression and Delirium

Check out all the different phenotypes investigated by our community below, visit our Phenotype Phebruary homepage or any of the individual threads, and then add your insights or learn from the great research done by our leads.
 

Feb. 1 • Type 2 Diabetes Mellitus
Feb. 2 • Type 1 Diabetes Mellitus
Feb. 3 • Atrial Fibrillation
Feb. 4 • Multiple Myeloma
Feb. 5 • Alzheimer’s Disease
Feb. 6 • Hemorrhagic Events
Feb. 7 • Neutropenia
Feb. 8 • Kidney Stones
Feb. 9 • Delirium
Feb. 10 • Systemic Lupus Erythematosus
Feb. 11 • Suicide Attempts
Feb. 12 • Parkinson’s Disease and Parkinsonism
Feb. 13 • Attention Deficit Hyperactivity Disorder
Feb. 14 • Hypertension (Video Description)
Feb. 15 • Acute Myocardial Infarction
Feb. 16 • Heart Failure
Feb. 17 • Cardiomyopathy
Feb. 18 • Multiple Sclerosis
Feb. 19 • Triple Negative Breast Cancer
Feb. 20 • Pulmonary Hypertension
Feb. 21 • Prostate Cancer
Feb. 22 • HIV
Feb. 23 • Hidradenitis Suppurativa
Feb. 24 • Anaphylaxis
Feb. 25 • Depression
Feb. 26 • Non-Small-Cell Lung Cancer
Feb. 27 • Drug-Induced Liver Injury
Feb. 28 • Disabilities: Severe Visual Impairment and Blindness
Bonus • Acute Kidney Injury

Phenotype Phebruary Homepage
EMA Announces OHDSI Collaborator Erasmus MC Will Initiate DARWIN EU Coordination Center

The European Medicines Agency (EMA) announced Feb. 9 that Erasmus University Medical Center Rotterdam has been contracted to establish the DARWIN EU (Data Analysis and Real World Interrogation Network) Coordination Centre.

The role of the Coordination Centre is to develop and manage a network of real-world healthcare data sources across the EU and to conduct scientific studies requested by medicines regulators and, at a later stage, requested by other stakeholders.

The vision of DARWIN EU is to give EMA and national competent authorities in EU Member States access to valid and trustworthy real-world evidence, for example on diseases, patient populations, and the use, safety and effectiveness of medicines, including vaccines, throughout the lifecycle of a medicinal product.

Peter Rijnbeek, a veteran OHDSI collaborator and Titan Award honoree, is the Chair of the Department of Medical Informatics of the Erasmus Medical Center.

EMA Announcement
The OHDSI community call is held every Tuesday at 11 am ET in our Microsoft Teams environment. These meetings will include research presentations, community updates, discussions, brainstorms, and plenty more. The meetings are open to everybody, and the link is available on our Community Calls page.

Maxim Moinat is a data engineer with a demonstrated history of working in bioinformatics and medical informatics. He has worked as a data engineer/software developer for The Hyve since 2016, and recently became a scientific researcher for the Erasmus MC medical informatics department. He has been a long-time collaborator with both the OHDSI and EHDEN  communities.

Maxim earned a 2021 Titan Award honoree for his invaluable contributions in data standards. He leads the Registry workgroup, contributes to open-source development and has provided tutorials and other presentations during global community calls. He said his passion is to apply his skills to advance biomedical science, ultimately improving healthcare for many patients.

Maxim recently shared several insights in our latest Collaborator Spotlight.

Collaborator Spotlight: Maxim Moinat
Publications

Lavallee, M., Yu, T., Evans, L. et al. Evaluating the performance of temporal pattern discovery: new application using statins and rhabdomyolysis in OMOP databasesBMC Med Inform Decis Mak 22, 31 (2022). https://doi.org/10.1186/s12911-022-01765-1

Burn, E., Li, X., Kostka, K., Stewart, H.M., Reich, C., Seager, S., Duarte-Salles, T., Fernandez-Bertolin, S., Aragón, M., Reyes, C., Martinez-Hernandez, E., Marti, E., Delmestri, A., Verhamme, K., Rijnbeek, P., Horban, S., Morales, D.R. and Prieto-Alhambra, D. (2022), Background rates of five thrombosis with thrombocytopenia syndromes of special interest for COVID-19 vaccine safety surveillance: incidence between 2017 and 2019 and patient profiles from 38.6 million people in six European countries. Pharmacoepidemiol Drug Saf. Accepted Author Manuscript. doi.org/10.1002/pds.5419

Cynthia Yang, Jan A Kors, Solomon Ioannou, Luis H John, Aniek F Markus, Alexandros Rekkas, Maria A J de Ridder, Tom M Seinen, Ross D Williams, Peter R Rijnbeek, Trends in the conduct and reporting of clinical prediction model development and validation: a systematic reviewJournal of the American Medical Informatics Association, 2022;, ocac002, doi.org/10.1093/jamia/ocac002

Pfaff, E., Haendel, M., Kostka, K., Lee, A., Niehaus, E., Palchuk, M., Walters, K., Chute, C. (2022). Ensuring a safe(r) harbor: Excising personally identifiable information from structured electronic health record data. Journal of Clinical and Translational Science, 6(1), E10. doi:10.1017/cts.2021.880

Presentations
Feb. 1: Phenotype Phebruary Introduction
Feb. 8: Healthcare Systems Special Interest Group Update | Open-Source Community Update | Phenotype Phebruary Report #1
Feb. 15: CDM Workgroup Update | Data Quality Workgroup Update | Phenotype Phebruary Report #2 
Feb. 22: ATLAS Workgroup Update | Medical Imaging Workgroup Update | Phenotype Phebruary Report #3
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